It can be synthesized only by some microorganisms (e.g. Phaffia rodozyma or Haematococcus pluvialis). Shen and Quek (2014) [38] investigated the encapsulation of astaxanthin using spray drying method to enhance its stability and application in food systems. A promising technology to produce nanometer particles is represented by the use of supercritical fluids in combination with nanoemulsions, which presents advantages over these two separated assets. Mezzomo et Carfilzomib molecular weight al. (2012) [39] related the use of high pressure method for the encapsulation of extracts enriched in astaxanthin from pink

shrimp residue. Emulsion-based systems are particularly suitable for encapsulating and delivering lipophilic bioactive components such as carotenoids. Regorafenib concentration The astaxanthin oleoresin is not as unstable as free astaxanthin and could be used as a natural pigment in the form of a water-dispersible emulsion [40]. Machado Jr. et al. (2014) [41] investigated the co-precipitation of astaxanthin from microalga H. pluvialis in the co-polymer poly(hydroxybutyrate-co-hydroxyvalerate) by supercritical fluids technique with supercritical carbon dioxide as anti-solvent. Encapsulation of drugs into nanoparticles has been demonstrated to possess several advantages compared to free drug administration. The envelope may provide a good solubility for rather hydrophobic drugs in an aqueous system and thereby increase their stability and duration of action [19]. Envisaging

industrial applications of the monodispersed emulsions formulated using the microchannel emulsification technique, the authors’ research group have developed a large

microchannel emulsification Ketotifen device including a newly designed asymmetric channels array to realize the mass production of uniformly sized droplets on a liter per hour scale [42]. The large emulsification device has a potential droplet productivity exceeding several tons per year, which could satisfy a minimum industrial-scale production of monodisperse micro-dispersions containing emulsion droplets, microparticles, and microcapsules loaded with bioactive compounds [3]. Such systems have a continuously increasing potential for application in the formulation of functional foods, providing a good opportunity to improve the solubility of bioactive compounds, so as to increase their bioavailability. Some of the dispersion systems introduced in this chapter have been increasingly used as controlled-release drug delivery systems, such as templates in the preparation of microcapsules for protection and controlled release of functional food components, or in the formulation of low-calorie foods. The peptide-loaded nanocapsules described herein may provide an important tool for controlling spoilage and pathogenic organisms in foods. Seemingly, the micro/nano-encapsulation may improve the stability and efficacy of astaxanthin and other carotenoids in food matrices. The authors have declared no conflict of interest.