Hepatic damage in dams was seen only in the multiple exposure gro

Hepatic damage in dams was seen only in the multiple exposure groups. PEGylated SWCNTs reached the conceptus when administered early in pregnancy and at later stages

it was detected in the placenta and the yolk sac but not in embryo [174]. Before the widespread utilization of CNTs in the medical science, it is important to note that the chronic toxicity of CNT must be experimentally studied and the appropriate safeguards must be taken against Inhibitors,research,lifescience,medical the possible interactions among the CNTs and biological systems. 7. Conclusion CNT represents a novel class of carriers for the delivery of drugs in a site specific and target oriented manner. CNTs possess extraordinary physical, chemical, and SRT1720 in vitro mechanical properties, which make them as a potent biological carrier to deliver anticancer drugs. Studies have clearly shown Inhibitors,research,lifescience,medical that functionalization of CNT and further derivatization with biodegradable polymers render them compatible with biological systems. Due to their unique chemistry, hexagonal arrangement Inhibitors,research,lifescience,medical of carbon atoms, various

sites are available for both covalent and noncovalent functionalization with the therapeutically active molecule or protein macromolecules which envisaged the potential of CNT as nanocarrier for the site specific delivery of therapeutic agent including peptides, proteins, nucleic acid, and other small drug molecules for targeting various cancer cells. These functionalized CNTs possess high propensity to traverse cell membrane either via endocytosis dependent or independent pathways. Thorough investigations have been performed in this review on various synthesis and modification routes for the production Inhibitors,research,lifescience,medical of purified CNTs and their role in combating cancer. Various ex vivo models based on different Inhibitors,research,lifescience,medical cancer cell lines were studied to determine the pharmacokinetic and pharmacodynamic parameters of anticancer compounds, that is, being carried by the biocompatible nanosized carbon tubes at the targeted site on cancer cells. All the observations

and results cited in this review evidently endorse the usefulness of functionalized CNTs as a potential carrier for the anticancer molecule to target the cancer cell without causing toxicity to other viable cells. Also, the usefulness of cell lines has greatly validated the Adenylyl cyclase results for the assessment of in vivo therapeutic and diagnostic efficacy for cancer treatment and reduces the dependency on animal and human models for the treatment of cancer at the preclinical and clinical study trial level. This compilation of the literature provides useful information to researchers for exploring the further scope of CNTs in the medical science. Conflict of Interests The authors declare that there is no conflict of interests regarding the publication of this paper.

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