22 The psychometric properties have been validated in large patie

22 The psychometric properties have been validated in large patient with CFS cohorts confirming that WSAS is a reliable assessment tool for disability. High scores Nutlin-3a Mdm2 correlate with severe fatigue and poor physical fitness.16 Fatigue was self-rated by the FSS scale. Based on change in FSS score change from baseline, contact 1, the disease course was defined; FSS change <−1 was defined as worsening course; FSS change ≥−1 and ≤1 was defined as no change; FSS change >1 was defined as improvement. Self-rated

global clinical outcome was scored as worsening, stable, improvement and recovered. Employment status, sickness and disability benefits were recorded providing objective evidence of disability. The study was approved by the local ethics committee. Informed, written consent was obtained from the patients. Statistics Student’s t test, χ2 test, Fisher’s exact test, and pair-wise correlation test were performed when appropriate. The FSS score was dichotomised and FSS score ≥5 defined as pathological fatigue. Stepwise backward logistic regression analyses were performed with dichotomised FSS score at contact

2 as dependent variable. Stepwise backward linear regression analyses with FSS at contact 2 and WSAS as dependent variables were performed. STATA V.12.0 was used for analyses. Results In total, 111 patients participated in the baseline evaluation. Postal questionnaires were completed and returned by 92 (83%) of these patients on follow-up (contact 2); 30

(33%) males and 62 (67%) females (contact 2). The mean age of the patients at the onset of CFS was 23.7 years (SD=7.3). Mean duration of CFS at the time of contact 1 was 4.7 years (SD=4.0), (median=3.2 years, IQR=1.9−6.4). Mean time from debut of CFS to contact 2 was 11.4 years (SD=4.3; median=10.3 years, IQR=8.5–13.5; range=4.7−23.8). At the time of mononucleosis 43 (47%) were employed at work and 48 (52%) were students (missing data in one patient). We do not report any data on the 19 (17%) who did not complete the follow-up. Employment at contact 1(92 patients) At contact 1 9 (10.2%) patients remained employed (1 full-time and 8 part-time), 12 patients (13.5%) were students and 70 patients (81%) were neither employed nor studying (missing data in one patient). One patient Anacetrapib (1%) was receiving partial DP and 7 patients (8%) were receiving full DP. Fourteen (15%) patients received partial long-term SA benefits, and 62 (67%) patients received full long-term sickness SA (missing data in 8 patients). Employment at contact 2 (primary measures; 92 patients) At contact 2 24 (27%) were fully employed, 25 (28%) were employed part-time and 40 (45%) were unemployed (missing data in three patients). One patient (1%) was a student.

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