3 and 4 The size, surface charge and surface hydrophilicity of microspheres have been found to be important in determining the fate of particles in vivo. 5 and 6 The microencapsulation techniques used include physical, physico-chemical and chemical methods. Solvent evaporation is the most extensively used method of

microencapsulation. 7 In the present investigation microcapsules were prepared by solvent evaporation technique.8 Losartan potassium (LP) is an effective antihypertensive drug but is extensively bound to plasma proteins and also causes gastrointestinal disorders, neutropenia, acute inhibitors hepatotoxicity, migraine and pancreatitis. It may therefore be more desirable to deliver this Quisinostat datasheet drug in a sustained release dosage form.9 Thus present study was focused on development of losartan potassium microcapsules by using solvent evaporation and to study the effect of method of preparation on physical properties and drug release profiles of losartan potassium microcapsules. Losartan potassium a gift sample obtained from Life Line pharmaceuticals limited, Vijayawada (India). Eudragit S100 was commercially processed from M/S Yarrow Chemical Products, Mumbai. All other solvents and chemicals

were of commercial grade. Required quantity of Eudragit S100 was taken in a vessel and dissolved in 1:1 mixture of methanol and acetone using a magnetic stirrer until a homogenous solution http://www.selleckchem.com/products/3-methyladenine.html was formed. To this solution the drug was added and stirred with a magnetic stirrer until the drug is dissolved and a 3-mercaptopyruvate sulfurtransferase clear solution was obtained. Then this solution was

slowly aspirated in to hot liquid paraffin which is maintained at 60 °C while stirring at 2000 rpm with mechanical stirrer. The stirring was continued for 15 min until a discrete microcapsules were formed. Then the microcapsules were separated from the hot liquid paraffin and dried ambient conditions. The microcapsule thus obtained were further subjected to evaluation of various physical parameters like angle of repose, compressibility index, particle size, % yield and encapsulation efficiency. The composition of various microcapsules was given in Table 1. The prepared microcapsules were evaluated of flow properties like angle of repose, compressibility index and for Carr’s index. Size distribution plays a very important role in determining the release characteristics of microcapsules. The average particle size of the microcapsules was analyzed by simple microscopic method. Approximately 100 microcapsules were counted for particle size using a calibrated optical microscope (magnus mlx-Dx).10 The percentage practical yield is calculated to know about percentage yield or efficiency of any method, thus it helps in selection of appropriate method of production.