(Circ Cardiovasc Genet. 2012;5:441-449.)”
“The present work described the disorder induced magnetic properties of Sr2FeMoO6 (SFMO) samples. The crystal structure and magnetic order of SFMO samples with nanosized grains were studied using x-ray diffraction spectrum, scanning electron microscope morphology, and magnetic Selleck PD98059 measurements. Thermal annealing of as prepared chemical routed materials showed an increase in grain size and in the magnetic moment per formula unit. A small

decrease in magnetic moment was noted at higher annealing temperature. At the same time, the ac susceptibility measurement indicated the presence of a magnetic spin glass phase in the material, coexisting with the ferromagnetic matrix. The observation of the magnetic glassy phase confirmed the presence of intrinsic disorder in the lattice structure of SFMO. The signature of intrinsic disorder in the samples, irrespective of annealing temperatures, is also realized from the splitting of temperature dependent field cooled learn more and zero field cooled magnetization curves. Such magnetic splitting in the temperature dependence

of magnetization curves is suppressed at a higher magnetic field. A careful analysis of the temperature and field dependent magnetization data provided more insight on the grain size dependent disorder in the double perovskite structure. (C) 2009 American Institute of Physics. [doi:10.1063/1.3236566]“
“Polychlorinated biphenyls (PCBs) are persistent organic pollutants present in human blood and milk. Exposure to PCBs during pregnancy and lactation leads to cognitive

impairment in children. Perinatal exposure to PCB 153 or PCB 126 impairs the glutamate-nitric oxide-cGMP pathway in cerebellum in vivo and learning ability in adult rats. The aims of this work were: (1) to assess whether long-term exposure of primary cultures of cerebellar neurons to PCB 153 or PCB 126 reproduces the impairment in the function of the glutamate-nitric oxide-cGMP pathway found in rat cerebellum in vivo; (2) to provide some insight on the steps of the pathway affected by these PCBs; (3) to assess whether the mechanisms of interference of the pathway are different for PCB 126 and PCB 153. Both PCB 153 and PCB 126 increase basal levels of cGMP by different mechanisms. PCB 126 increases the amount of soluble guanylate cyclase while PCB 153 does not. PCB 153 reduces the amount selleck products of calmodulin while PCB 126 does not. Also both PCBs impair the function of the glutamate-nitric oxide-cGMP pathway by different mechanisms, PCB 153 impairs nitric oxide-induced activation of soluble guanylate cyclase and increase in cGMP while PCB 126 does not. PCB 126 reduces NMDA-induced increase in calcium while PCB 153 does not. When PCB 153 and PCB 126 exhibit the same effect, PCB 126 was more potent than PCB 153, as occurs in vivo.”
“Background-Atrial fibrillation (AF) is the most common cardiac arrhythmia. The cardiac sodium channel, Na(v)1.