Each board member not only has to be passionate in this mission but also should be capable of transmitting our mission to his/her country as an ambassador.

Based on discussions in the last consecutive meetings, the International Advisory Council reached a conclusion that it was time to move forward for a real action plan to improve the situation. In order to start a real action, we launched four work groups (Table 2). The first work group is for validation of eGFR equations and creatinine standardization. Two different GFR equations are currently used in Japan and China, and the ethnic coefficients for the US Modification of Diet in Renal Disease equation are also different between these countries. Because these

Asian eGFR equations were not created by a GFR reference method, the work group will compare two methods: inulin clearance Ulixertinib and diethylene triamine pentaacetic acid plasma clearance. The second objective of this work group is to support countries in validating these Asian equations for their own ethnicity. The validation of the Japanese equation is currently under operation in Taiwan and Korea. The third objective is to standardize creatinine measurements. As the first step, the work group will compare the results of mTOR inhibitor the isotope dilution mass spectrometry (ISDM)-traceable creatinine method for standard creatinine solution among different countries. If a systemic error exists, a plasma sample will be shipped to the central laboratory for calibration. The second work group is for the Pan-Asian CKD registry and risk analysis. This work group will collect existing registry data and analyze

the methodology in each registry. As the second step, the work group will establish a common methodology, which enables us to compare the data among different countries and areas. The third work group is for publishing a CKD guideline for Asia–Pacific people. Despite the availability of all the existing guidelines (e.g. KDIGO, CARI, EBPG, K/DOQI), the members all agreed that PRKACG there was a need for the development of the guideline under the AFCKDI for the people in Asia–Pacific region. The work group will study existing guidelines for CKD by other organizations and reference them. The work group will make recommendations taking into consideration the available evidences and local implementation factors including socioeconomic ones. The work group will produce statements/guidelines/practice points on areas of screening, evaluation and treatment in different stages of CKD. The last work group is for launching and managing a new portal website for the CKD initiative in the Asia–Pacific region by the AFCKDI.