% Gd, 1 mol. % La and 1 mol. % (La+Fe)-doped Pb(Zr(0.54)Ti(0.46)) O(3)). Applying uniaxial pressure leads to a reduction of the peak intensity of the electric permittivity (epsilon), of the frequency dispersion, and of the dielectric hysteresis. The peak intensity of epsilon becomes diffused and shifts to a higher temperatures with increasing pressure. Simultaneous application of uniaxial pressure and dc electric field (perpendicular to each other) in the poling

process implies in improvement of the ferroelectric properties, indicating a new possibility selleckchem for poling materials with a high coercive field and/or high electric conductivity. It was also found that simultaneous application of uniaxial pressure and dc electric field (perpendicular to each other) allowed observation of the space charge in the depolarization process. The electrostrictive coefficient Q(11) and differential permittivity were evaluated from obtained data. Our results show that applying uniaxial pressure induces similar effects as increasing the Ti-ion concentration in the PZT system. We interpreted our results based on the Cochran soft-mode and domain switching processes under

BV-6 the action of pressure. (C) 2011 American Institute of Physics. [doi:10.1063/1.3585826]“
“Sequencing the human genome was the big challenge of the last decade. Ten years later, the large amount of DNA sequences accumulated in our databases allows us to look at genome variations between humans. The level of complexity of these variations is much higher than previously expected. It goes from changes in the nucleotidic sequence, such as single nucleotide polymorphisms (SNPs) or copy number variations (CNVs), to modifications in DNA transcription or methylation. Indeed, epigenetics, with chromatin modifications and underlying crosstalk between DNA methylation, histone tails acetylation and non coding RNAs, as microRNAs, all participate to this non-encoded gene expression

regulation. Understanding the extent of genomic diversity between humans and linking it to phenotypes beta-catenin signaling and diseases, unravelling the environmental exposures that may be detrimental for our health is the next challenge of the geneticists. The decrypting of the epigenome and the exposome is now on its way.”
“SAPHO syndrome is a disorder involving the skin, bone and joints. The underlying causes of SAPHO are poorly understood, and treatment is, therefore, directed towards the individual symptoms. However, many patients are refractory to treatment, and new treatment options are needed. Herein, we describe a 28-year-old patient with SAPHO syndrome and palmoplantar pustulosis seen at our hospital. Treatment was initiated with non-steroidal anti-inflammatory drugs, but clinical improvement was poor. The addition of sulfasalazine and oral alendronate also failed to alleviate symptoms. We subsequently commenced treatment with adalimumab 40 mg every 15 days and suspended bisphosphonates.