“
“In the absence of evidence-based regulations on the driving ability of patients with psychogenic nonepileptic seizures

(PNES), we asked 41 German epileptologists via e-mail for their recommendations on driving with PNES. This survey was modeled on an earlier study by Benbadis et al. [11] in the United States and was compared with it. Thirty-four (82.9%) epileptologists responded. Three responses were possible: (A) same restrictions as stipulated for patients with epilepsy, answered by 11 epileptologists (32.4%): (B) no restrictions at all, which no German expert gave as an answer (0%); (C) decision on an individual basis, answered by 23 experts (67.6%). The divergent approaches reflect the poor data on motor vehicle accidents Selleck BMS-777607 of patients with PNES and the great variability of PNES with respect to sentiology, psychiatric morbidity, and prognosis. In the study by Benbadis et al., 49% chose A, 32% B, and 19% C. The considerable national differences may be explained by differences between the two countries

with respect to driving regulations and cultural aspects. (C) 2009 Elsevier Inc. All rights reserved.”
“Objective: To investigate the diagnostic value of abdominal ultrasound in HIV-positive inpatients in a rural African setting.

Methods: This was a prospective case series over 3 months of adult HIV-positive patients with symptoms suggestive of abdominal tuberculosis mTOR inhibitor (TB). Diagnostic ultrasound was performed for all patients: sonographic https://www.selleckchem.com/products/fosbretabulin-disodium-combretastatin-a-4-phosphate-disodium-ca4p-disodium.html criteria included abdominal lymph node enlargement (> 1.5 cm) and focal splenic lesions; ascites was a supportive finding. Further diagnostic studies, e. g., aspiration or biopsy were not routinely performed. TB treatment was initiated on the basis of clinical and sonographic features. The patients were contacted after 4 months to evaluate the clinical outcome.

Results: One hundred and eighty adult HIV-positive patients were screened; 30 (16.7%) showed sonographic signs of abdominal TB. The median CD4 count was 78 cells/mm(3). Presenting symptoms were weight loss (86.7%),

abdominal pain (76.7%), and diarrhea (60%). Abdominal lymph node enlargement was the diagnostic finding in almost all cases (96.7%); hypoechoic lesions of the spleen were seen in 50% and ascites in 73.3%. Follow-up information was available for 25 patients: 24% had died and the remaining 76% reported symptomatic improvement and weight gain.

Conclusions: Characteristic sonographic features of abdominal TB are common in HIV-infected inpatients in a rural African setting. Ultrasound should be introduced into clinical algorithms for the diagnosis of extrapulmonary TB. (C) 2010 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.”
“Aim: KW-2170 is a novel pyrazoloacridone derivative that intercalates nucleic acids.