Initially the value of using key additional clinical observations made by the surgeon at the time of operation was quickly dismissed by pathologists at St Mark’s Hospital, London. In particular Basil Morson, argued that the burden of including such CT99021 mw information as part of routine reporting was beyond the scope of a busy pathology department with a heavy service commitment and a practical impossibility,

given that the relevant operative findings were invariably not available at the time of issuing the final report. (Personal communication to P.C.). At St Mark’s this shortfall was partly compensated for by including, with every report sent out by the Pathology Department, a set of definitions explaining various terms such as “radical” and “palliative”, based on the assessment made by the surgeon at the time of operation. In essence therefore although patients’ tumors were presumably classified solely according to an examination of the resected specimen, the interpretation of the definitive tumor selleck compound stage was made very much in the light of the operative findings. In other words, classical Dukes’ tumor “stage” was reported only for patients whose tumor was resected and who, in the opinion of the surgeon, had undergone a potentially curative operation. Here, then, was the semblance of a clinicopathological approach. The confusion

and shortcomings surrounding the original Dukes’ pathological staging generated a compelling and urgent need for international multi-disciplinary co-operation to produce a comprehensive format for the reporting and staging of CRC which would be acceptable to all stakeholders. This matter was highlighted in a chronological review published in March 1991,7 just prior to the Working Party Report to the World MCE公司 Congresses of Gastroenterology which heralded the post-Dukes’ era. The principal conclusion by the authors then was that it was inappropriate to introduce yet another system of staging CRC considering the already widespread acceptance of the Tumor-Node-Metastases

(TNM) system jointly promulgated by the Union Internationale Contre le Cancer (UICC) and the American Joint Committee on Cancer (AJCC),8 and used throughout Europe and North America, respectively. It was also recommended that a minimum data set for the reporting of CRC (International Documentation System-IDS) and a standard terminology (International Comprehensive Anatomical terminology-ICAT) be adopted in order to link the six internationally recognized CRC staging systems used at the time. These were: pTNM, the Australian Clinicopathological Staging System (ACPS), the Concord Hospital Staging System, Dukes’ system, the Astler-Coller system and the Japanese Research Society system.4 In 1999 the ICAT/IDS recommendations were adopted in Australia and endorsed in the NHMRC Clinical Practice Guidelines for Staging and Reporting CRC.