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Int J Cancer 2007, 121:567–75.PubMedCrossRef 27. Suzuki M, Hao C, Takahashi T, Shigematsu H, Shivapurkar N, Sathyanarayana UG, Iizasa T, Fujisawa T, Hiroshima K, Gazdar AF: Aberrant methylation of SPARC in human lung cancers. Br J Cancer 2005, 92:942–8.PubMedCrossRef 28. Sato N, Fukushima N, Maehara N, Matsubayashi this website H, Koopmann J, Su GH, Hruban RH, Goggins M: SPARC/osteonectin is a frequent target for aberrant methylation in pancreatic adenocarcinoma and a mediator of tumor stromal interactions. Oncogene 2003, 22:5021–30.PubMedCrossRef 29. Yan Q, Sage EH: SPARC, a matricellular glycoprotein with important biological functions. J Histochem Cytochem 1999, 47:1495–506.PubMed 30. Chlenski A,

Liu S, Guerrero LJ, Yang Q, Tian Y, Salwen

HR, Zage P, Cohn SL: SPARC expression is associated with impaired tumor growth, inhibited angiogenesis and changes in the extracellular KU55933 price matrix. Int J Cancer 2006, 118:310–6.PubMedCrossRef 31. Norose K, Clark JI, Syed NA, Basu A, Heber-Katz E, Sage EH, Howe CC: SPARC deficiency leads to early-onset cataractogenesis. Invest Ophthalmol Vis Sci 1998, 39:2674–80.PubMed 32. Jendraschak E, Sage EH: Regulation of angiogenesis by SPARC and angiostatin: implications for tumor cell biology. Semin Cancer Biol 1996, 7:139–46.PubMedCrossRef 33. Kupprion C, Motamed K, Sage EH: SPARC (BM-40, osteonectin) inhibits the mitogenic effect of vascular endothelial growth factor on microvascular endothelial cells. J Biol Chem 1998, 273:29635–40.PubMedCrossRef 34. Yunker CK, www.selleckchem.com/products/gm6001.html Golembieski W, Lemke N, Schultz CR, Cazacu S, Brodie C, Rempel SA: SPARC induced increase in glioma matrix and decrease in vascularity are associated with reduced VEGF expression and secretion. Int J Cancer 2008,

122:2735–43.PubMedCrossRef Calpain 35. Chlenski A, Liu S, Crawford SE, Volpert OV, DeVries GH, Evangelista A, Yang Q, Salwen HR, Farrer R, Bray J, Cohn SL: SPARC is a key Schwannian derived inhibitor controlling neuroblastoma tumor angiogenesis. Cancer Res 2002, 62:7357–63.PubMed 36. Tang MJ, Tai IT: A novel interaction between procaspase 8 and SPARC enhances apoptosis and potentiates chemotherapy sensitivity in colorectal cancers. J Biol Chem 2007, 282:34457–67.PubMedCrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions JFL, HX and HXZ were equally involved in the design of the study and drafted the manuscript. HKW was involved in the design of the study, patient recruitment, management of the patients, statistical analysis and drafted the manuscript. JZG and RBB carried out most of the experiments. CXC, NL, YBM and YZZ participated in data organization and manuscript drafting. All authors read and approved the final manuscript.”
“Background The liver is a common site of metastatic disease. Hepatic metastases can originate from a wide range of primary tumours (e.g.

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