Mesenchymal stem cells offer an attractive alternative cell-source for cartilage repair, due to their ease of isolation and amenability to ex vivo expansion while retaining stem cell properties. Preclinical and clinical studies have demonstrated the potential of mesenchymal stem cells to promote articular cartilage repair, but have also highlighted several key challenges.
Most notably, the quality and durability of the repair tissue, its resistance to endochondral ossification, and its effective integration with the surrounding host tissue. In addition, challenges exist related to the heterogeneity of mesenchymal stem cell preparations and their quality-control, as well as optimising the delivery method. Finally, as our knowledge of the cellular and molecular mechanisms underlying articular cartilage repair increases, promising studies are emerging employing bioactive scaffolds or therapeutics that elicit an effective tissue www.selleckchem.com/products/defactinib.html repair response this website through activation and mobilisation of endogenous stem and progenitor cells. (C) 2013
Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.”
“In the present paper, the associations between residential traffic noise exposure from the noise sources – road, rail and aircraft – and self-reported indicators of health and well-being are investigated in a representative sample of the Swiss population. The study is based on record linkage of the Swiss GIS Noise Database (Son Base) and the Swiss Household Panel (SHP), a large panel survey with more than 10,000 respondents all over the country. A range of exposure-effect relationships of noise exposure and parameters of health and well-being such as self-reported health status, satisfaction with health, sleep disturbances, the intensity of the wish to move from the current residence as well as the awareness of “”noise problems”" at the place of living were investigated. Both unadjusted as well as models that Elafibranor chemical structure controlled for age, sex, socioeconomic status, degree of urbanization at the
place of residence, and personal living conditions were developed. A contribution of residential noise exposure as regards subjective estimates of health cannot been ruled out, but must be put into perspective as the effects of exposure measures were of rather small magnitude, especially compared to well-established determinants of health. Against the background of the explanatory power of classic health predictors, the present analyses allow one to gage the contribution of residential noise exposure on subjective health outcomes from a more general, integral point of view. (C) 2011 Elsevier Ltd. All rights reserved.”
“Objective: To examine the efficacy of a multidisciplinary non-pharmacological intervention in patients with hand osteoarthritis (OA).
Method: Parallel group randomized controlled trial was performed in three participating rheumatology outpatient clinics in the Netherlands.