Meta-analysis of CBT Now that BT is firmly established, several meta-analyses have been carried out. The latest meta-analysis71 included 77 studies with 4651 patients and showed that BT was superior to

SSRI antidepressants as a class. Nevertheless, this difference should be taken with caution as BT is limited by the problem of availability, accessibility, and third-party payment in many countries. CT in OCD The status of CT is still under investigation and there have recently been some new studies published (Table IV).72-79 Inhibitors,research,lifescience,medical To date, the usefulness of CT for OCD has been assessed in 8 controlled studies. Emmelkamp et al72 did not find a superior effect, when adding cognitive modifications Inhibitors,research,lifescience,medical to in vivo exposure. Nevertheless, the design of the experiment, aimed at. teaching the patient, to replace negative thoughts by positive ones. This could have been used as neutralizing thoughts. Emmelkamp et al73 compared CT without exposure to self-managed exposure. Six months after the end of treatment, both groups showed equivalent, reduction in rituals, generalized anxiety,

and social anxiety. Only the cognitive group showed change on the measures of depression. In a study with a more impaired population, Emmelkamp and Beens74 found similar results at a 6-month follow-up. Van Oppen et al75 randomized 71 patients in either Beckian CT or exposure. After 16 sessions, they Inhibitors,research,lifescience,medical found a superiority of cognitive interventions over exposure. Danger schemata were better modified by CT than with exposure. Unfortunately, this study had

no long-term follow-up. A multicentered study (76) compared CT with intensive BT. Sixty-five ambulatory patients with DSM-IV OCD and without major depression were randomized Inhibitors,research,lifescience,medical into two groups for a. 16-week psychological treatment: either CT, or exposure and response prevention, for a 4-week intensive treatment period followed by a maintenance phase of 12 weeks. No medication was prescribed. At week 16, the rates of responders were comparable in the two groups. Depression (bipolar type I) was Inhibitors,research,lifescience,medical significantly more improved in the group that received CT. At weeks 26 and 52, improvement was retained in both groups without a between-group difference. Cognitive measures of obsessions changed equally in the two groups. This study replicated on a larger scale the findings of Emmelkamp and coworkers.73,74 Table VI. Cognitive out http://www.selleckchem.com/EGFR(HER).html therapy (CT) in obsessive-compulsive disorder: controlled studies. BT, behavior therapy; CBT; cognitive behavior therapy; ERP; exposure and response prevention; SSRI, selective serotonin reuptake inhibitor. Freeston et al77 presented a study comparing a waiting list with a group treated with CBT. In a group of OCD patients with exclusively covert, rituals, that the superiority of CBT over the waiting list was maintained at 6 months’ follow-up. Jones and Mcnzies78 found that CT was superior to a waiting list at. posttest only.