Objective. To determine the viability and safety of Reverse Smith Petersen Osteotomy (RSPO) to re-established sagittal balance in patients with fixed lumbar hyperlordosis.
Summary and Background Data. Lumbar hyperlordosis is seen as a compensatory mechanism in thoracic Scheuermann disease and in sagittal decompensation in severe neuromuscular scoliosis. Hyperlordosis may also be seen after overcorrection with spinal osteotomies, but rarely causes clinically significant negative sagittal imbalance because of the thoracic compensation.
We describe a case using www.selleckchem.com/products/lazertinib-yh25448-gns-1480.html a kyphosing osteotomy to treat hyperlordosis in a patient that was treated with a pedicle subtraction osteotomy for post-Harrington kyphosis.
Methods. The radiographs and clinical chart were reviewed of a patient treated with a RSPO at L2-L3 to correct the negative sagittal imbalance created by a previous extension of her fusion to the sacrum with a pedicle subtraction osteotomy.
Results. A reduction in the lumbar lordosis by 20 at L2-L3 and restoration
of the global sagittal balance was achieved with the RSPO.
Conclusion. RSPO is a viable surgical technique that can be used to re-establish sagittal balance in patients with fixed lumbar hyperlordosis. Appreciation of a patient’s balanced sagittal alignment and available compensatory mechanisms can help ensure SRT2104 chemical structure appropriate osteotomies are performed.”
“P>Idiopathic pulmonary fibrosis (IPF) is a frequent indication for lung transplantation (LTX) with pulmonary hypertension (PH) negatively affecting outcome. The optimal procedure type remains a debated topic. The aim of this study was to evaluate the impact of pretransplant PH in IPF patients. Single LTX (SLTX, n = 46) was the standard procedure type. Double LTX (DLTX, n = 30) was only performed in cases of relevant PH or additional suppurative lung disease. There was no significant
difference for pretransplant clinical parameters. Preoperative mean pulmonary arterial pressure was significantly higher in DLTX recipients (22.7 +/- 0.8 mmHg vs. 35.9 +/- 1.8 mmHg, P < 0.001). After transplantation, 6-min-walk PRT062607 distance and BEST-FEV(1) were significantly higher for DLTX patients (6-MWD: 410 +/- 25 m vs. 498 +/- 23 m, P = 0.02; BEST-FEV(1): 71.2 +/- 3.0 (% pred) vs. 86.2 +/- 4.2 (% pred), P = 0.004). Double LTX recipients demonstrated a significantly better 1-year-, overall- and Bronchiolitis obliterans Syndrome (BOS)-free survival (P < 0.05). Cox regression analysis confirmed SLTX to be a significant predictor for death and BOS. Single LTX offers acceptable survival rates for IPF patients. Double LTX provides a significant benefit in selected recipients. Our data warrant further trials of SLTX versus DLTX stratifying for potential confounders including PH.”
“The aim of the study is to examine the associations of sleep characteristics with health-related quality of life (HRQOL) and sleep health disparities among US young adults using national survey data.