Physicians should consider diagnosis of SS in patients with clinical suspicious history as sometimes skin manifestations are the first sign of systemic presentation of disease.”
“Objective: The choice of a shock-first or a cardiopulmonary resuscitation (CPR)-first strategy in the treatment of prolonged cardiac arrest (CA) is still controversial. The purpose of this study was to compare the effects of these strategies on oxygen
metabolism and resuscitation outcomes in a porcine model of 8 min CA.
Methods: Ventricular fibrillation (VF) was electrically induced. After 8 min of untreated VF, 24 male inbred Wu-Zhi-Shan miniature pigs were randomized to receive either defibrillation first (ID group) selleck chemicals or chest compression first (IC group). In the ID group, a shock was delivered immediately. If the defibrillation attempt failed to attain restoration of spontaneous circulation (ROSC), manual chest compressions were rapidly initiated at a rate of 100 compressions min(-1), and the compression-to-ventilation ratio was 30:2. If VF persisted after five cycles of CPR, a second defibrillation attempt was made. In the IC group,
chest compressions were delivered first, followed by a shock.
Results: Hemodynamic variables, the VF waveform and Panobinostat purchase blood gas analysis outcomes were recorded. Oxygen metabolism parameters and the amplitude spectrum area (AMSA) of the VF waveform were computed. There were no significant differences in the rate of ROSC and 24 h survival between two groups. The ID group had lower lactic acid levels, higher cardiac output, R406 manufacturer better oxygen consumption and better oxygen extraction ratio at 4 and 6 h after ROSC than the IC group.
Conclusions: In a porcine model of prolonged CA, the choice of a shock-first or CPR-first
strategy did not affect the rate of ROSC and 24 h survival, but the shock-first strategy might result in better hemodynamic status and better oxygen metabolism than the CPR-first strategy at the first 6 h after ROSC. (C) 2012 Elsevier Ireland Ltd. All rights reserved.”
“Glutathione S-transferase (GST) inhibition-directed fractionations on the ethanolic extract of Artocarpus nobilis of Sri Lankan origin yielded four known triterpenoids, cyclolaudenyl acetate (1), lupeol acetate (2), beta-amyrine acetate (3), and zizphursolic acid (4), along with five known flavonoids, artonins E (5), artobiloxanthone (6) artoindonesianin U (7), cyclocommunol (8) and multiflorins A (9). Our recent chemical studies on the methanolic extract of Matricaria chamomilla, collected from Manitoba, afforded one new compound, matriisobenzofuran (10), and six known natural products, fraxidin (11), scopoletin (12), apigenin (13), apigenin 7-O-beta-glucopyranoside (14), palmatoside A (15) and p-hydroxyacetophenone (16). Compounds 1-16 were identified with the aid of extensive NMR and MS spectral data. Compounds 1-16 exhibited a wide range of GST inhibition activity.