Rhabdomyosarcoma (RMS) is a cancerous soft muscle tumor that is the reason approximately one-half of soft muscle sarcomas in childhood age ranges. Metastatic RMS is an unusual problem occurring within just 25% of patients at diagnosis and will have adjustable medical presentations. Here we report a 17-year-old kid with reputation for losing weight, fever and generalized bone pain accepted for severe hypercalcemia. The definite diagnosis of RMS ended up being done with immune-phenotyping of the metastatic lymph-node biopsy. The main cyst web site had not been found. Their bone scan revealed diffuse bone metastasis and considerable smooth muscle technetium uptake as a result of extra-osseous calcification. Metastatic RMS can mimic lymphoproliferative conditions at presentation. Clinicians should be aware for this diagnosis particularly in youngsters.Metastatic RMS can mimic lymphoproliferative conditions at presentation. Clinicians should be aware of this diagnosis particularly in adults.An 80-year-old man with an about 3-cm mass when you look at the correct submandibular region provided to the establishment. Magnetized resonance imaging revealed enlarged lymph nodes (LNs) within the right throat, and fluorine-18-2-deoxy-D-glucose (FDG) positron emission tomography (PET)/computed tomography (CT) suggested positive FDG buildup within the right throat LNs just. Excisional biopsy ended up being done for suspected malignant lymphoma, while the biopsy disclosed melanoma. Close examination of the skin, nasal cavity, oral pharyngeal and laryngeal cavities, and gastrointestinal tract were performed read more . No major tumefaction was detected by these exams, plus the patient was clinically determined to have cervical LN metastasis from melanoma of unknown primary of clinical stage T0N3bM0 stage IIIC. The patient declined cervical throat dissection due to his age and comorbidity of Alzheimer’s disease condition and rather chosen proton ray treatment (PBT) at a complete dosage of 69 Gy (general biological effectiveness) in 23 fractions. He didn’t receive any systemic treatment. The enlarged LNs shrunk slowly, and FDG PET/CT at one year after PBT showed that just the right submandibular LN had shrunk from 27 to 7 mm in length, and there was clearly no considerable FDG buildup. At 6 many years and 4 months after PBT, the individual is live without having any recurrence.Uterine adenosarcoma is a rare gynecologic malignancy, and 10-25% associated with situations show genetic stability medically intense habits. Although TP53 mutations are generally identified in high-grade adenosarcomas associated with the uterus, definitive gene changes have not been identified in uterine adenosarcomas. Especially, no reports have actually explained mutations in homologous recombination deficiency-related genes in uterine adenosarcomas. This study presents a case of uterine adenosarcoma without sarcomatous overgrowth however with TP53 mutation that exhibited medically intense habits. The in-patient had an ATM mutation, which is a gene associated with homologous recombination deficiency, and exhibited an excellent reaction against platinum-based chemotherapy and possible therapeutic target by poly(ADP-ribose) polymerase inhibitors.Total pancreatectomy (TP) after proximal gastrectomy (PG) requires more attention than ordinary TP during surgery in terms of the conservation of the flow of blood towards the remnant stomach that was supplied via only the correct gastric and gastroepiploic arteries. Current report provides the facts of an instance Colorimetric and fluorescent biosensor where the remnant tummy was safely preserved when carrying out TP. A 74-year-old man which underwent PG for gastric cancer 17 years previously had been identified as having pancreatic mind cancer during follow-up for intraductal papillary mucinous neoplasm for the pancreatic human body and end. To protect digestive function and minimize postoperative problems, TP preserving the best gastroepiploic artery and splenic vessels ended up being done. The remnant tummy and purpose had been properly maintained without having any complications after surgery. Self-medication is ever more popular among people in developing nations like Nepal where the expenditure of healthcare is reasonably high and non-prescription) medications are commonly and easily obtainable. Even though this technique features particular advantages, additionally, it is obvious it has many downsides, such as the possibility of negative medicine responses, medication opposition, medicine communications, and increased morbidity and mortality. This study aimed to guage making use of self-medication in nine wards of Kathmandu Metropolitan City (ward number 4, 5, 13, 15, 16, 17, 23, 31, and 32). This cross-sectional descriptive survey was conducted when you look at the plumped for wards of Kathmandu Metropolitan town for 3 months from August to October 2021. A semi-structured questionnaire was used to collect data from 372 patients who have been searching for self-medication. The members were selected arbitrarily. Self-medication was common among folks (78%). Probably the most regular afflictions which is why members self-medicated were the normal cool (17.1%), heaevalence of self-medication in Kathmandu city had been ascertained by evaluating the rehearse among residents associated with Kathmandu Metropolitan city. The research showed self-medication is frequent among men and women and for that reason, proper education about drug use and self-medication will become necessary.