Present results are obviously similar to the results explained above which shows that bilirubin level increases due to malarial infection. Present study also shows that hypoglycemia is more common in sever malaria patients. 68% of patients were found with hypoglycemia. We detected hypoglycemia in nearly 11% of the patients with sever falciparum malaria. Shah et al 11 reported hypoglycemia in 2 out of 20 cases (10%) of severe falciparum malaria from Karachi (Pakistan). The occurrence of malaria in adults is due to mal-absorption of glucose from intestine. Thai adults with sever malaria had

greatly reduced absorption capacity for sugar transport both actively and passively. 12 Most of our patients have hypoglycemia before quinine administration. selleck chemicals llc This suggests that other causes may also be responsible for hypoglycemia. 13 All authors have none to declare. We are very thankful to Professor Dr. Salman Akbar Malik Chairman

Department of Biochemistry, QAU Islamabad, Pakistan for his valuable suggestions. “
“Multi-particulate (MP) modified release drug delivery systems have several performance advantages over single unit dosage forms. MP formulations generally have a more reliable in vivo dissolution performance, resulting in more uniform bioavailability and clinical effect. 1 Pelletization is an agglomeration process that converts fine powders or granules of bulk drugs and excipients into small, free flowing, spherical or semi spherical below units, referred to as pellets. 2 Pellets offer a high degree of flexibility and can be divided into desired dose strengths without formulation or process changes. 3 Pellets are in LDK378 in vitro a size range between 0.5 and 1.5 mm and are produced primarily for the purpose of oral controlled release dosage forms having gastro resistant or sustained release properties or the capability of site-specific drug delivery. 4 The pelletized products can improve the safety and efficacy of the active agent, showing a number of advantages over the single unit dosage

system. 5 Extended release formulations are designed to allow at least twofold reduction in dosing frequency or significant increase in patient compliance or therapeutic performance when compared to a conventional immediate release dosage form. 6 Sustained release pharmaceutical pellet is one of the most popular approaches among the various types of extended release dosage forms as it offers several manufacturing and biopharmaceutical advantages. 7 Pellets are also less affected by gastric emptying. 8 After administration, the coated pellets spread uniformly throughout the gastrointestinal tract resulting in a consistent drug release with reduced risk of local irritation and dose dumping of the drug can be avoided. NSAIDs are a group of drugs of diverse chemical composition and different therapeutic potentials.9 Most NSAIDs are weak acids, with a pKa values in the range of 3.0–5.0 and contain hydrophilic groups and lipophilic ones.