Psychological resilience literature collected from the Web of Science core Collection between January 1, 2010, and June 16, 2022, was subjected to analysis with CiteSpace58.R3.
8462 literary sources were identified and selected after the screening. Recent years have shown an expansion in the field of psychological resilience research. The United States' involvement in this field was substantial and impactful. Robert H. Pietrzak, George A. Bonanno, Connor K.M., and others had a powerful and far-reaching impact.
It possesses the highest citation frequency and centrality measures. Investigations into psychological resilience, specifically in the context of the COVID-19 pandemic, are clustered around five core research areas: influencing factors, resilience and PTSD, resilience in special populations, and the molecular biology and genetic underpinnings of resilience. The most advanced and innovative research focus during the COVID-19 pandemic was psychological resilience.
The current investigation of psychological resilience trends and patterns, as described in this study, may provide insight into significant emerging challenges and opportunities for future research.
This study delved into the current state of psychological resilience research and its emerging trends, offering a framework for identifying critical topics and opening new avenues for research exploration.
Recalling past experiences, classic old movies and TV series (COMTS) can do so effectively. Personality traits, motivation, and behavior provide a theoretical framework for understanding how nostalgia can lead to repeated viewing habits.
An online survey was implemented to assess the connection between personality traits, feelings of nostalgia, social connectedness, and the behavioral intent of repeated movie or TV show viewing by those who had rewatched (N=645).
Individuals exhibiting openness, agreeableness, and neuroticism, based on our results, were more likely to experience nostalgia, leading to a behavioral intention of repeated viewing. In conjunction, social connectedness plays a mediating part in the link between agreeable and neurotic tendencies and the desire to repeatedly view something.
Our research indicates that individuals characterized by openness, agreeableness, and neuroticism were more predisposed to feeling nostalgia, thereby fostering the behavioral intention of repeated viewing. In the case of agreeable and neurotic individuals, social connectedness serves as a mediator between these personality traits and the intention to repeatedly engage in viewing something.
This paper describes a high-speed data transmission method between the cortex and skull, leveraging digital-impulse galvanic coupling, a novel approach. The proposed wireless telemetry, intended to replace the tethered wires connecting cortical implants to those positioned above the skull, facilitates a free-floating brain implant, which consequently minimizes harm to the surrounding brain tissue. The trans-dural wireless telemetry system's wide channel bandwidth enables high-speed data transfer, and its small form factor guarantees minimal invasiveness. The propagation behavior of the channel is analyzed using a finite element model. This is supported by a channel characterization study employing a liquid phantom and porcine tissue. Measurements of the trans-dural channel indicate a frequency response that spans up to 250 MHz, as shown by the results. This work includes an investigation into the propagation loss caused by micro-motion and misalignments. The data indicates the proposed transmission method's comparative insensitivity to misalignment issues. Approximately 1 dB more loss is incurred with a 1mm horizontal misalignment. The pulse-based transmitter ASIC and a miniature PCB module were meticulously crafted and confirmed effective ex vivo, using a 10-mm thick sample of porcine tissue. Miniature, in-body galvanic-coupled pulse communication, demonstrated in this work, attains a high data rate of up to 250 Mbps and an impressively low energy consumption of 2 pJ/bit, all contained within a compact module area of 26 mm2.
In the past few decades, the utility of solid-binding peptides (SBPs) has become increasingly evident within materials science. Solid-binding peptides, a versatile and simple instrument in non-covalent surface modification strategies, offer a straightforward method for the immobilization of biomolecules onto a wide array of solid surfaces. The biomolecule display properties of hybrid materials, particularly in physiological environments, can benefit from SBPs, resulting in tunable characteristics and minimal impact on the biomolecules' functionality. Due to the inherent features of SBPs, they are an attractive option for the manufacturing of bioinspired materials in diagnostic and therapeutic applications. The incorporation of SBPs has been particularly advantageous for biomedical applications such as drug delivery, biosensing, and regenerative therapies. This review examines recent literature concerning the application of solid-binding peptides and proteins across diverse biomedical domains. Applications in which the modulation of the connection between solid materials and biomolecules is paramount are our focus. This review examines solid-binding peptides and proteins, exploring the intricacies of sequence design and the mechanistic underpinnings of their binding. Following this, we examine the practical implementations of these concepts on materials used in biomedicine, encompassing calcium phosphates, silicates, ice crystals, metals, plastics, and graphene. While the narrow characterization of SBPs represents a hurdle for their development and broad adoption, our review demonstrates the easy incorporation of SBP-mediated bioconjugation into multifaceted designs and nanomaterials featuring various surface chemistries.
The controlled release of growth factors on a bio-scaffold is the key to achieving successful critical bone regeneration in tissue engineering. Gelatin methacrylate (GelMA) and hyaluronic acid methacrylate (HAMA) have become a key focus in bone regeneration, particularly when supplemented with nano-hydroxyapatite (nHAP) for improved mechanical properties. Reports indicate that exosomes originating from human urine-derived stem cells (USCEXOs) are capable of promoting osteogenesis in tissue engineering procedures. The current research project was dedicated to creating a novel GelMA-HAMA/nHAP composite hydrogel as a drug delivery vehicle. For improved osteogenesis, USCEXOs were encapsulated within the hydrogel and released gradually. Controlled release performance and appropriate mechanical properties were observed in the characterization of the GelMA hydrogel sample. The USCEXOs/GelMA-HAMA/nHAP composite hydrogel, in vitro, promoted the creation of bone in bone marrow mesenchymal stem cells (BMSCs) and the development of blood vessels in endothelial progenitor cells (EPCs). Meanwhile, the experimental results, obtained from living rats, confirmed that this composite hydrogel strongly stimulated the repair process of cranial bone defects. Our findings additionally indicated that the composite hydrogel, composed of USCEXOs/GelMA-HAMA/nHAP, could promote the formation of H-type vessels within the bone regeneration area, thereby bolstering the therapeutic effect. Ultimately, our research indicated that the biocompatible and controllable USCEXOs/GelMA-HAMA/nHAP composite hydrogel may effectively stimulate bone regeneration through the synergistic promotion of osteogenesis and angiogenesis.
Triple-negative breast cancer (TNBC) exhibits a unique dependence on glutamine, a characteristic amplified by its heightened susceptibility to glutamine deprivation. The conversion of glutamine to glutamate, facilitated by glutaminase (GLS), is a pivotal step in the biosynthesis of glutathione (GSH). This downstream metabolic process is critical to the acceleration of TNBC cell proliferation. Sulbactampivoxil Subsequently, interventions focused on glutamine metabolism potentially offer therapeutic approaches to TNBC. However, the results achieved with GLS inhibitors are challenged by the resistance to glutamine and their own intrinsic instability and insolubility. Sulbactampivoxil Accordingly, the aim of optimizing TNBC therapy is served by a synchronized glutamine metabolic intervention. Unhappily, no practical implementation of this nanoplatform has been seen. A nanoplatform (BCH NPs) integrating GLS inhibitor Bis-2-(5-phenylacetamido-13,4-thiadiazol-2-yl)ethyl sulfide (BPTES) and photosensitizer Chlorin e6 (Ce6) with a human serum albumin (HSA) shell was designed and reported. This self-assembling platform enables improved glutamine metabolic interventions for TNBC therapy. The glutamine metabolic pathways were blocked by BPTES's inhibition of GLS activity, which in turn reduced GSH production and amplified Ce6's photodynamic effect. Ce6's impact on tumor cells went beyond the direct induction of reactive oxygen species (ROS), encompassing the depletion of glutathione (GSH), thereby disrupting redox balance and reinforcing the effectiveness of BPTES during instances of glutamine resistance. The effective eradication of TNBC tumors and suppression of tumor metastasis by BCH NPs is further supported by their favorable biocompatibility. Sulbactampivoxil New light is shed on photodynamic-mediated glutamine metabolic manipulation in TNBC through our research.
Increased postoperative morbidity and mortality are observed in patients who exhibit postoperative cognitive dysfunction (POCD). A key factor in the emergence of postoperative cognitive dysfunction (POCD) is the overproduction of reactive oxygen species (ROS) and the resultant inflammatory cascade within the postoperative brain. Still, the means to prevent POCD are still elusive. Importantly, the effective passage through the blood-brain barrier (BBB) and the preservation of life within the body are major challenges to preventing POCD when employing traditional reactive oxygen species scavengers. Synthesis of mannose-coated superparamagnetic iron oxide nanoparticles (mSPIONs) was achieved through the co-precipitation method.