(72.20 kg [95% CI 66.55 to 80.75]) p = 0.06, this was not significant. This discrepancy was attenuated when BMI was compared between the groups of cases and controls (30.50 kg/m2 [95% CI 28.50 to 32.69]) vs. (28.89 kg/m2 [95% CI 27.78 to 31.12]) p = 0.15, respectively. The metabolic variables were not statistically different in levels of

adiponectin, leptin, insulin, TNF alpha, total CRT0066101 clinical trial cholesterol, triglycerides, HDL, LDL, and levels of free fatty acids. There was only a significant difference in median fasting glucose, 74 mg/dl (95% CI 73 to 78.96) in the case group vs. 84 mg/dl (80.26 buy Z-DEVD-FMK to 88.0) in the control group (p = 0.003); while the median HOMA was 2.2 (95% CI 1.6 to 3.0) vs. 2.9 (CI 95% 2.3 to 5.2) for cases Temsirolimus supplier and controls, respectively (p = 0.047). D‡   Control (A) n = 15 Case (B) n = 17   Control (C) n = 15 Case (D) n = 17       Age, y § 21.5 ± 2.19 20.3 ± 1.44 0.08 72.40 (65.66 – 82.08) 76.30 (69.90 – 82.22) 0.39 0.80 0.0003* Weight, kg. 30.88) 28.80 (27.50 – 30.78) 0.74 0.76 0.0002* FM kg 26.7 (23.15 – 31.26) 32.6 (23.51 – 34.4) 0.08 27.60 (23.50 – 31.01) 29.40 (23.12 – 33.07) 0.67 0.58 0.0005* FFM kg 45.70 (42.13 – 48.26) 48.70 (46.20 – 50.29) 0.08 44.80 (41.75 – 47.94) 47.90 (45.80 – 49.39) 0.06 0.13 0.03* Waist cm 83 (80.38 – 88) 86.40 P-type ATPase (82.02 – 91.98) 0.24 82.50 (79.76 – 86.15) 83 (79.50 – 86) 0.74 0.11 < 0.0001* Hip cm 108 (102.26 – 110.62) 112.5 (105.04 – 115.46) 0.07 106.5 (102.52 – 108.73) 108 (103 – 111) 0.76 0.54 0.0002* Waist to Hip Ratio 0.79 (0.76 - 0.81) 0.78 (0.77 - 0.81) 0.80

0.77 (0.75 – 0.80) 0.78 (0.75 – 0.79) 0.63 0.27 0.04* Adiponectin ug/ml 11.54 (7.88 – 15.26) 11.72 (7.29 – 15.06) 0.61 12.33 (8.36 – 15.60) 15.76 (9.96 – 23.44) 0.32 0.80 < 0.0001* Leptin ng/ml 30.33 (25.30 – 36.06) 28.31 (23.82 – 35.12) 0.71 29.42 (21.51 – 37) 18.13 (12.94 – 24.31) 0.002* 0.45 0.03* TNFa pg/ml 4.44 (4.10 – 6.14) 4.33 (2.90 – 5.31) 0.25 5.05 (4.12 – 6.76) 4.10 (3.53 – 4.98) 0.036* 0.12 0.93 Insulin, mg/dl 13.72 (11.47 – 24.95) 12.01 (8.64–16.74) 0.14 12.73 (10.70 – 19.43) 12.89 (6.42 – 14.37) 0.12 0.01* 0.17 Glucose, mg/dl 84 (80.26 – 88) 74 (73–78.96) 0.003* 86 (82.26 – 87) 82 (76.01 – 87) 0.39 0.80 0.05* CHOL, mg/dl 78 (59.05 – 149.02) 78 (62.03 – 111.79) 0.69 78 (65.79 – 113) 66 (59.03 – 99-95) 0.15 0.59 0.33 TGL mg/dl 160 (144.52 – 182.41) 153 (144.04 – 186.98) 0.87 165 (149.70 – 186.73) 168 (152.01 – 184.