We also show that the extent to which the compliance of the substrate modulates the growth rate of adhesion site depends on the areal density of cell-adhesive ligands on the substrate. (c) 2010
Elsevier Ltd. All rights reserved.”
“Five iodinated 2-phenyl- l H-benzo[d]imidazole derivatives were synthesized and evaluated as potential probes for beta-amyloid (A beta) plaques. One of the compounds, 4-(6-iodo- l H-benzo[d]imidazol-2-yl)-N,N-dimethylaniline (12), showed excellent affinity for A beta(1-42) aggregates (K(i)=9.8 nM). Autoradiography with sections of postmortem Alzheimer’s disease (AD) brain revealed that a radioiodinated probe [(125)I]12, labeled A beta plaques selectively with low nonspecific Sonidegib binding. Biodistribution experiments
with normal mice injected intravenously with [(125)I]12 showed high uptake [4.14 percent injected close per gram (% ID/g) at 2 min] into and rapid clearance (0.15% lD/g at 60 min) from the brain, which may bring about a good signal-to-noise ratio and therefore achieve highly sensitive detection of A beta plaques. In addition, [(125)I]12 labeled amyloid plaques in vivo in an AD transgenic model. The preliminary results strongly suggest that [(125)I]12 bears characteristics suitable for detecting amyloid plaques in vivo. When labeled with (123)I, it may be a useful SPECT imaging agent for A beta plaques in the brain of living Pritelivir mouse AD patients. (C) 2011 Elsevier Inc. All rights reserved.”
“We propose a theory of evolution of social systems which generalizes the standard proportional fitness rule of the evolutionary game theory. The formalism is applied to describe the dynamics of two-person one-shot population games. In particular it predicts the non-zero level of cooperation in the long run for the Prisoner’s
Dilemma games, the increase selleck kinase inhibitor of the fraction of cooperators for general classes of the Snow-Drift game, and stable nonzero cooperation level for coordination games. (c) 2010 Elsevier Ltd. All rights reserved.”
“Introduction: Nuclear and optical imaging are complementary in many aspects and there would be many advantages when optical imaging probes are prepared using radionuclides rather than classic fluorophores, and when nuclear and optical dual images are obtained using single imaging probe.
Methods: The luminescence intensities of various radionuclides having different decay modes have been assayed using luminescence imaging and in vitro luminometer. Radioiodinated Herceptin was injected into a tumor-bearing mouse, and luminescence and microPET images were obtained. The plant dipped in [P-32]phosphate solution was scanned in luminescence mode. Radio-TLC plate was also imaged in the same imaging mode.
Results: Radionuclides emitting high energy beta(+)/beta(-) particles showed higher luminescence signals. NIH3T6.7 tumors were detected in both optical and nuclear imaging.