We found that gaps exist in many resource categories, even under scenarios in which few cases occur. Such gaps are likely to be profound if a severe pandemic occurs. These gaps exist in infrastructure, personnel and materials, and surveillance capacity. Policy makers must determine whether such resource gaps can realistically be closed, ideally before a pandemic occurs. Alternatively, explicit assumptions must be made regarding allocation of scarce resources, standards of care, and priority setting during a pandemic.”
“Context and Objective: Plumbagin (2-methyl, 5-hydroxy, 1, 4-naphthoquinone),
an anticancer agent is encapsulated either as conventional or long circulating liposomal formulations to enhance its biological half-life and antitumor efficacy.
Methods: The liposomes were prepared by thin film hydration method and in vitro characterization was carried out to examine the particle size, zeta potential, drug see more encapsulation efficiency and in vitro release. The optimized formulations were tested for pharmacokinetic and pharmacodynamic efficacy against mice bearing B16F1 melanoma. Also in vivo toxicity studies were carried out.
Results and Discussion: The optimum particle size and entrapment MAPK inhibitor efficiency was observed at drug to lipid molar ratio of 1: 20. The in-vitro release of plumbagin from the liposomal formulations in phosphate-buffered saline (pH 7.4) showed
biphasic release with an initial burst release followed by sustained release phase. Elimination half life (T(1/2)) of pegylated, conventional and free plumbagin was 1305.76 +/- 278.16, 346.87 +/- 33.82 and 35.89 +/- 7.95 min respectively. Further, plumbagin exhibited better antitumor efficacy in vivo when administered as long circulating liposomes with no signs of normal tissue toxicity.
Conclusion: It can be concluded that the pegylated liposomes could provide a promising parenteral platform for plumbagin with enhanced plasma half-life and therapeutic efficacy.”
“In this work, KU-57788 order we communicate on the synthesis, characterization, and ionic
conductivity of a series of novel crosslinked inorganicorganic gel polymer electrolytes. These crosslinked polymers were prepared by the modification of poly(vinyl alcohol) (PVA) with poly(ethylene glycol) (PEG) in the presence of borane-tetrahydrofuran (BH3/THF) complex. During crosslinking, the polymer was doped with lithium trifluoromethane-sulfonate (CF3SO3Li) salt. Molecular weight of both PVA and PEG was varied, and the concentration of Li-salt was arranged for the ratio of lithium atoms to ether oxygen atoms. Boron-containing polymer electrolytes were produced and abbreviated as PVA1PEGX-Y and PVA2PEGX-Y. The reaction of PEG with PVA and the interaction of Li+ ions with EO units were confirmed by FTIR. Thermal stability of these materials was measured with thermogravimetric analysis, and thermal behaviors were measured by differential scanning calorimetry.