Interestingly, Li-7 NMR lines of nano-Li2O2 undergo pronounced heterogeneous motional narrowing which manifests in a two-component line shape emerging with increasing temperatures. Most likely, the enhancement in sigma can be traced back to the generation of a spin reservoir with highly mobile Li ions; these are expected to reside in the nearest neighbourhood of defects generated or near the structurally disordered and defect-rich interfacial regions formed during mechanical treatment.”
“Background: Primary immune selleck inhibitor deficiency (PID) due to humoral defects is associated with recurrent respiratory tract infections (RTIs). Reliable clinical warning signs of PID would facilitate early
diagnosis and thereby reduce long-term complications. The aim of the present study was to evaluate the accuracy of the warning sign, ‘four or more antibiotictreated RTIs annually for 3 or more consecutive years,’ for detecting PID among adults in a primary health-care setting. Methods: Fifty-three cases with ‘four or more antibiotic-treated RTIs annually for 3 or more consecutive years ‘ were selected from a Swedish primary Erastin clinical trial health-care registry of RTIs. In addition, 66 age-and sex-matched controls were selected having a maximum of one antibiotic-treated RTI during the period covered by the study. Levels of immunoglobulin (Ig) IgG, IgA, IgM, IgG subclasses, and IgG antibodies against Haemophilus influenzae and Streptococcus pneumoniae
as well as the inflammatory markers, C-reactive protein, interleukin (IL)-6 and IL-8 were determined. Results: IgG subclass deficiencies (IgGsd) were found in 5/53 (9.4%) of the cases and in 7/66 (10.6%) controls. The most frequent deficiency was IgG3sd and this was found in three participants in the case group and seven in the control group. The mean level of IgG3 was lower in the control group (p = 0.02). The mean level of IL-8 was lower in the case group (p = 0.02). Conclusion: The results show that physicians working in primary health care cannot
solely rely on the frequency of antibiotic-treated RTIs as a warning sign for the detection of common humoral immune deficiencies.”
“Mulberry 1-deoxynojirimycin (DNJ) shows high a-glucosidase inhibitory, antioxidant, antimicrobial, and anti-inflammatory activity. This is a widely used functional food constituent in China, Japan, Korea, Thailand and many other Repotrectinib ic50 Asian countries. In this study, the DNJ content of mulberry leaves from 132 varieties of nine Morus species was determined. The degree of maturity of the mulberry leaves affected the DNJ content significantly. The younger leaves contained higher DNJ concentrations than did the older leaves. DNJ concentrations in mature leaves varied among these 132 mulberry varieties from 0.1341 to 1.472 mg/g of dry leaves. DNJ content in leaves was variety dependent and had no obvious relationship with either the species or their place of origin. Crown Copyright (C) 2013 Published by Elsevier B.V. All rights reserved.
57.0%; P < 0.01), and with CL at G1 (94.0% vs. 67.8%; P < 0.01). Double-Ovsynch also increased the percentage of cows with high P4
(>3.0 ng/mL) at PCF2 alpha (88.0% vs. 76.3%; P = 0.04) and tended to increase average circulating P4 at PGF(2 alpha) (3.52 +/- 0.17 ng/mL vs. 3.09 +/- 0.21 ng/mL; P = 0.11). Double-Ovsynch also tended to increase percentage of cows ovulating to G1 (80.0% vs. 69.9%; P = 0.11) and G2 (98.0% vs. 93.5%; P = 0.08). Thus, presynchronization of cows with Double-Ovsynch induced ovulation in noncycling cows and appeared to increase most aspects of synchronization during the Ovsynch protocol. (C) 2013 Elsevier Inc. All www.selleckchem.com/products/hsp990-nvp-hsp990.html rights reserved.”
“Magnetoacoustic detection is a new method for the noninvasive, early detection of cancer. It uses specific superparamagnetic nanoparticles (NPs) that bind to tumor sites together with magnetic excitation and acoustic detection of the tumor-NPs complex. This work
tests the feasibility of such method theoretically and experimentally. An extensive analytic model has been developed that shows an ability to detect small tumors, a few centimeters deep inside the tissue. A series of experiments were conducted to validate selleck the theoretical model. The performance of specially designed solenoids was measured, and the detection of the tumor presence in phantom was demonstrated. Experimental results agree well with the theoretical calculations, providing preliminary proof of concept. We demonstrate the ability to detect a 5-mm diameter spherical tumor located 3 cm deep. Instrumentation and measurements are inexpensive and accurate. The accuracy, speed, and costs of this method show the potential for early detection of cancer.”
are common, frequently see more devastating, and benefit from timely diagnosis and treatment. Point of care (POC) technologies have the potential to assist clinicians caring for these patients. In order to prioritize development of new POC testing, a thorough assessment of clinical needs is required. We describe the methods of the clinical needs assessment (CNA) process and provide the initial findings of a CNA for POC technologies in neurologic emergencies performed to support a National Institute of Biomedical Imaging and Bioengineering (NIBIB) initiative.\n\nCNA is an iterative process. An initial survey instrument was developed through consensus by a multi-disciplinary panel and underwent internal validation through beta-testing and face-validity assessment. This survey was distributed at the national meetings of several academic medical societies and results were used to redesign of the survey tool for broader distribution. Analysis of responses from the revised survey supported the release of a request for proposals (RFP) in 2010. Survey revision continues, and expanded CNA efforts with focus groups are being designed in anticipation of another RFP in 2012.\n\nThe initial survey identified six areas of clinical need and two domains of interest.
Three drug mixing
ratios are considered. While an increase in the carrier particle www.selleckchem.com/products/Mizoribine.html size has a mild improvement on the ED, it significantly improves the FPF. A sparse surface asperity has negligible effect on the ED at low flow rates but it improves the FPF compared to a dense surface asperity under all experimental conditions. (C) 2011 Elsevier B.V. All rights reserved.”
“In this study, we report the previously unknown mechanism of inducing robust anti-melanoma immunity by the vitiligo-inducing compound monobenzone. We show monobenzone to increase melanocyte and melanoma cell immunogenicity by forming quinone-haptens to the tyrosinase protein and by inducing the release of tyrosinase-and melanoma antigen recognized by T cells-1 (MART-1)-containing CD63+ exosomes following melanosome oxidative stress induction. Monobenzone further augments the processing
and shedding of melanocyte-differentiation antigens by inducing melanosome autophagy and enhanced https://www.selleckchem.com/products/CX-6258.html tyrosinase ubiquitination, ultimately activating dendritic cells, which induced cytotoxic human melanoma-reactive T cells. These T cells effectively eradicate melanoma in vivo, as we have reported previously. Monobenzone thereby represents a promising and readily applicable compound for immunotherapy in melanoma patients.”
“Total plasma gamma-glutamyltransferase (GGT) activity is a sensitive, non-specific marker of liver dysfunction. Four GGT fractions (b-, m-, s-, f-GGT) were described in plasma and their differential specificity in the diagnosis of liver diseases was suggested. Nevertheless JQ-EZ-05 fractional GGT properties have not been investigated yet. The aim of this study was to characterize the molecular nature of fractional GGT in both human plasma and bile. Plasma was obtained from healthy volunteers; whereas bile was collected from patients undergoing liver transplantation. Molecular weight (MW), density, distribution by centrifugal sedimentation and sensitivity
to both detergent (deoxycholic acid) and protease (papain) were evaluated. A partial purification of b-GGT was obtained by ultracentrifugation. Plasma b-GGT fraction showed a MW of 2000 kDa and a density between 1.063-1.210 g/ml. Detergent converted b-GGT into s-GGT, whereas papain alone did not produce any effect. Plasma m-GGT and s-GGT showed a MW of 1,000 and 200 kDa, and densities between 1.006-1.063 g/ml and 1.063-1.210 g/ml respectively. Both fractions were unaffected by deoxycholic acid, while GGT activity was recovered into f-GGT peak after papain treatment. Plasma f-GGT showed a MW of 70 kDa and a density higher than 1.21 g/ml. We identified only two chromatographic peaks, in bile, showing similar characteristics as plasma b- and f-GGT fractions.
7%. The odds ratio for predicting an unfavourable neurological outcome was 0.921 (95% CI 0.853-0.985). The likelihood to remain in a poor neurological condition decreased by 7.9% for each additional point of BIS, on average. Conclusion: Our results suggest that BIS and SR are helpful tools in the evaluation of the neurological outcomes of resuscitated
patients. Bromosporine solubility dmso Nevertheless, therapeutic decisions have to be confirmed through further examinations due to the far-ranging consequences of false positive results. (C) 2013 Elsevier Ireland Ltd. All rights reserved.”
“BACKGROUND & AIMS: Stem and progenitor cells exist in normal postnatal livers. However, it has not been possible to clonally isolate or analyze postnatal liver stem/progenitor-like cells (PLSCs) derived from noninjured livers because of a lack of specific surface markers. This study aimed to establish a primary culture system for clone-sorted PLSCs. METHODS: To investigate proliferation and differentiation of PLSCs, Daporinad Metabolism inhibitor subpopulations of nonparenchymal cells derived from noninjured livers were purified and cultured using a single-cell culture system. Cells were grown in feral liver cell-derived conditioned medium in the presence of the Rho-associated
kinase (ROCK) inhibitor Y-27632. RESULTS: We identified CD13 and CD133 as markers expressed on the PLSC-containing population in noninjured livers and established an efficient single-cell Culture system to clonally analyze PLSCs. Culture of PLSCs is difficult, even using conditioned medium, but the addition of Y-27632 increased PLSC cell proliferation. The proportion of progenitor cells among nonparenchymal cells decreased during postnatal liver development; however, a PLSC population was still preserved in 3-month-old mice. Long-term cultivated cells derived from clone-sorted cells in PKC412 order normal livers were established and were called normal-liver-derived
stem-like cells (NLS cells). NLS cells could differentiate into hepatocyte-like and cholangiocyte-like cells under appropriate culture conditions and under-went self-renewal-like activity in serial reclone-sorted culture. CD13 and CD133 were expressed on progenitor cells derived from fetal and postnatal liver, whereas CD49f (integrin alpha 6 subunit) was strongly expressed only on PLSCs. CONCLUSIONS: These results demonstrate the presence of progenitor cells in the CD13(+)CD49f(+)CD133(+) subpopulation of nonhematopoietic cells derived from noninjured postnatal livers.”
“This article presents a survey of metacercariae found in tadpoles of 6 amphibian species collected near the city of Corrientes, Corrientes Province, Argentina. Larval digenetic trematodes of the following species were found: (1) Travtrema aff. stenocotyle Cohn, 1902 (Plagiorchiidae) from Physalaemus santafecinus, Physalaemus albonotatus, Odontophrynus americanus, Elachistocleis bicolor, Scinax nasicus, and Leptodactylus latinasus; (2) Styphlodora sp. (Plagiorchiidae) from O. americanus and E.
“The codoping effect of antimony on the photocatalytic activity of visible-light-driven SrTiO3 doped with rhodium (SrTiO3:Rh) was investigated. SrTiO3 doped with rhodium and antimony (SrTiO3:Rh/Sb) prepared by a hydrothermal method was found to be active for photocatalytic H-2 evolution PXD101 nmr from an aqueous methanol solution and O-2 evolution from an aqueous silver
nitrate solution under visible light irradiation, although SrTiO3 doped with rhodium and no antimony was active only for the H-2 evolution. Photocatalytic activities of SrTiO3:Rh/Sb were strongly dependent on the ratio of codopant to dopant (Sb/Rh). Diffuse reflection spectroscopy (DRS), electron spin resonance (ESR), Raman, and action spectrum analyses revealed the contribution of rhodium and antimony to visible-light compound screening assay response of SrTiO3:Rh/Sb. Unstable and reversible Rh3+ ions in oxidation state were the superior species for the H-2 evolution. On the other hand, Rh3+ ions stabilized by codoping of antimony without the formation of Rh4+ ions and oxygen
defects which would work as undesirable recombination sites between photogenerated electrons and holes played an important role in the O-2 evolution. Moreover, when an IrOx cocatalyst was loaded on the surface of the SrTiO3:Rh/Sb photocatalyst, the photocatalytic activity of the O-2 evolution drastically increased. The apparent quantum yield for the H-2 evolution over Pt(0.3 wt%)/SrTiO3:Rh(1%)/Sb(1%) and the O-2 evolution over IrOx(3.0
wt%)/SrTiO3:Rh(1%)/Sb(1%) at 420 nm were 0.8% and 4.5%, respectively. The Z-scheme system composed of Ru(1.0 wt%)/SrTiO3:Rh(2%) selleck as a H-2-evolving photocatalyst, IrOx(3.0 wt%)/SrTiO3:Rh(1%)/Sb(1%) as an O-2-evolving photocatalyst, and an Fe3+/Fe2+ redox couple as an electron mediator showed photocatalytic activity for overall water splitting under visible light irradiation. (C) 2013 Elsevier B.V. All rights reserved.”
“Nonadherence to maintenance medication is common in paediatric chronic conditions. Despite the common belief that nonadherence is therapy-resistant, and the apparent lack of evidence for successful interventions to improve adherence, there is, in fact, a considerable body of evidence suggesting that adherence can be improved by applying specific communicative consultation skills. These can be summarized as the adherence equation: adherence = follow-up + dialogue + barriers and beliefs + empathy and education = bigger than concordance. Close follow-up of children with a chronic condition is needed to establish a therapeutic partnership with the family. Teaching self management skills is not a unidirectional process of providing information, but requires a constructive and collaborative dialogue between the medical team and the family. Identifying barriers to adherence can be achieved in a non-confrontational manner, by showing a genuine interest what the patient’s views and preferences are.
94). The marked increase in adiponectin induced by rosiglitazone was not associated with significant changes in basal endogenous glucose production (P
= 0.90), basal lipolysis (P = 0.90), insulin-mediated suppression of glucose production (P = 0.17) and lipolysis (P = 0.54) nor with changes in peripheral glucose disposal (P = 0.13). Acknowledging the limited statistical power of our small study, these findings, if confirmed by larger studies, could question the importance of adiponectin in regulating glucose metabolism in HIV-lipodystrophy.”
“NADH:ubiquinone oxidoreductase (complex I) is a complicated respiratory enzyme that conserves the energy from NADH oxidation, coupled to ubiquinone reduction, as a proton motive force across the mitochondrial inner membrane. During catalysis, NADH oxidation by a flavin mononucleotide is followed by electron transfer to a chain of iron-sulfur clusters. check details Alternatively, the flavin may be reoxidized MX69 inhibitor by hydrophilic electron acceptors, by artificial electron acceptors in kinetic studies, or by oxygen and redox-cycling molecules to produce reactive oxygen species. Here, we study two steps in the mechanism of NADH oxidation by complex I. First, molecular fragments of NAD(H), tested as flavin-site inhibitors or substrates, reveal that the adenosine moiety is crucial for binding. Nicotinamide-containing fragments
that lack the adenosine do not bind, and ADP-ribose binds more strongly than NAD(+), suggesting that the nicotinamide is detrimental to binding. Second, the primary kinetic isotope effects from deuterated nicotinamide nucleotides confirm that hydride transfer is from the pro-S position Tariquidar and reveal that hydride transfer, along with NAD(+) dissociation,
is partially rate-limiting. Thus, the transition state energies are balanced so that no single step in NADH oxidation is completely rate-limiting. Only at very low NADH concentrations does weak NADH binding limit NADH:ubiquinone oxidoreduction, and at the high nucleotide concentrations of the mitochondrial matrix, weak nucleotide binding constants assist product dissociation. Using fast nucleotide reactions and a balance between the nucleotide binding constants and concentrations, complex I combines fast and energy-conserving NADH oxidation with minimal superoxide production from the nucleotide-free site.”
“The purpose of the present study was to collect data from population-based cancer registries and to calculate relative 5-year survival of cancer patients in Japan. We also sought to determine time trends and to compare the results with international studies.\n\nWe asked 11 population-based cancer registries to submit individual data for patients diagnosed from 1993 to 1999, together with data on outcome after 5 years. Although all these registries submitted data (491 772 cases), only six met the required standards for the quality of registration data and follow-up investigation.
Mass of brain, liver, and kidneys was measured by MRI and mass of heart was estimated by echocardiography. Normal levels of thyroid hormone (triiodothyronine: T-3) were confirmed in all subjects prior to the analysis. Multiple regression analysis was used to assess the influence of FFM, fat mass (FM), T-3, and mass of organs on
variance of REE. Average body weight and FFM were 81.2 +/- 11.3 kg and 67.7 +/- 7.4 kg, respectively. The relative contributions of liver, kidneys, and heart to REE were consistent regardless of FFM, while the REE of brain was negatively correlated with FFM (r=-0.672, p<0.001). Only FFM and T-3 were found to be independent factors influencing REE. These results suggest that a steady contribution of internal organs other than the brain
Selleck ABT737 is the major reason for the consistency of the REE/FFM ratio in male power athletes.”
“The ecological Protein Tyrosine Kinase inhibitor and evolutionary consequences of variation in behaviour between individuals are well studied, yet the causes of such variation remain poorly understood. Parents can generally exert a great deal of influence on the early life of their offspring, so one possibility is that the mode of parental investment determines subsequent offspring behaviours. In birds, hatching asynchrony occurs when females begin incubation prior to clutch completion, and the subsequent hatching regime creates phenotypic disparities between early and late-hatched offspring. By experimentally manipulating hatching patterns in zebra finches, Taeniopygia guttata, we examined the influence of hatching asynchrony on subsequent exploratory behaviour during SC79 ic50 adulthood. Late-hatched birds from asynchronous broods explored the novel environment more than their siblings which hatched earlier or came from synchronous broods, although
there were no differences in exploratory behaviour towards a novel object. Additionally, females were bolder towards a novel object than were males, independently of hatching regime, but there were no sex differences in exploration of the novel environment. Our results support the idea that both hatching asynchrony and sex have previously underappreciated influences on offspring behaviours, and highlight the importance of variation in parental investment in generating and maintaining behavioural variation. (C) 2012 The Association for the Study of Animal Behaviour. Published by Elsevier Ltd. All rights reserved.”
“Single leg loading tests are used clinically to examine balance and loading strategies in individuals with lower limb pain. Interpretation of these tests is through pain responses and comparisons with the asymptomatic leg. The purpose of this study was to examine normal differences in trunk and pelvic movement between legs during the single leg stand, single leg squat, hip hitch and hip drop tests, and to compare observational and quantitative assessments of trunk movement during the single leg squat test.
Four new site point mutants showing the effects of side-chain alteration at subunit interfaces are also enzymatically characterised. The LmPYK tetramer crystals grown with ammonium sulphate as precipitant adopt an active-like conformation, with sulphate ions at the active and effector sites. The sulphates occupy positions similar to those of the phosphates of ligands bound Baf-A1 purchase to active (R-state) and constitutively active (nonallosteric) PYKs from several species, and provide insight into the structural roles
of the phosphates of the substrates and effectors. Crystal soaking in sulphate-free buffers was found to induce major conformational changes in the tetramer. In particular, the unwinding of the A alpha 6′ helix and the inward hinge movement of the B domain are coupled with a significant widening (4 angstrom) of the tetramer caused by lateral movement of the C domains.
The two new LmPYK structures and the activity studies of site point mutations described in this article are consistent with a developing picture of allosteric activity in which localised changes in protein flexibility govern the distribution of conformer families adopted by the tetramer in its active and inactive states. (C) Rabusertib in vivo 2008 Elsevier Ltd. All rights reserved.”
“NMDA receptors are a subclass of ionotropic glutamate receptors. They are trafficked and/or clustered at synapses by the post-synaptic density (PSD)-95 membrane associated guanylate kinase (MAGUK) family of scaffolding proteins that associate with NMDA receptor NR2 subunits via their C-terminal glutamate serine (aspartate/glutamate) valine motifs. We have carried out a systematic study investigating in a heterologous expression system, the selleck compound association of the four major NMDA receptor subtypes with the PSD-95 family of MAGUK proteins, chapsyn-110, PSD-95, synapse associated protein (SAP) 97 and SAP102. We report that although each PSD-95 MAGUK was shown to co-immunoprecipitate
with NR1/NR2A, NR1/NR2B, NR1/NR2C and NR1/NR2D receptor subtypes, they elicited differential effects with regard to the enhancement of total NR2 subunit expression which then results in an increased cell surface expression of NMDA receptor subtypes. PSD-95 and chapsyn-110 enhanced NR2A and NR2B total expression which resulted in increased NR1/NR2A and NR1/NR2B receptor cell surface expression whereas SAP97 and SAP102 had no effect on total or cell surface expression of these subtypes. PSD-95, chapsyn-110, SAP97 and SAP102 had no effect on either total NR2C and NR2D subunit expression or cell surface NR1/NR2C and NR1/NR2D expression. A comparison of PSD-95 alpha, PSD-95(3 and PSD-95 alpha(C3S,C5S) showed that PSD-95-enhanced cell surface expression of NR1/NR2A receptors was dependent upon the PSD-95 N-terminal C3,C5 cysteines.
We believe that the Ponseti method should be used in all cases of nonidiopathic CTEV.”
“Our objectives were to standarize the procedure needed to reproduce a similar surgical scene which a pediatric surgeon would face on repairing a Bochdalek hernia
in newborns and to define the optimal time period for hernia development that achieve a realistic surgical scenario with nninimimal animal suffering. Twenty New Zealand white rabbits weighing 3-3.5 kg were divided into four groups depending on the time frame since hernia creation to thoracoscopic repair: 48 h, 72 h, 96 h and DNA Damage inhibitor 30 days. Bochdalek trigono was identified and procedures for hernia creation and thoracoscopic repair were standarized. Blood was collected for hematology (red blood cells, white blood cells, platelets, hemoglobin and hematocrit), biochemistry (blood urea nitrogen, creatinine, alanine aminotransferase, aspartate
aminotransferase, lactate dehydrogenase and creatine kinase) and gas analysis (arterial blood pH, partial pressure of oxygen, partial pressure of carbon dioxide, oxygen saturation and bicarbonate) at baseline and before the surgial repairment. Glucocorticoid metabolites concentration in faeces was measured. Thoracoscopy video recordings were evaluated by six pediatric surgeons and rated from 0 to 10 according to similarities with congenital diaphragmatic hernia in newborn and with its thoracoscopic approach. Statistical methods included the analysis of variance, and comparisons between groups were followed by a post-hoc Tukey’s test. Fourty -eight h showed to selleck chemical be the optimal time frame to obtain a diaphragmatic hernia similar to newborn scenario from a surgical point of view with minimal stress for the animals.”
“A particular interaction-diffusion mussel-algae model system for the development of spontaneous stationary young mussel bed patterning on a homogeneous substrate covered by a quiescent marine layer containing algae as a food source is investigated employing weakly nonlinear diffusive instability analyses. The main results of these analyses can be represented by plots in the ratio of mussel motility to algae lateral diffusion versus
the algae reservoir concentration dimensionless EPZ5676 parameter space. Regions corresponding to bare sediment and mussel patterns consisting of rhombic or hexagonal arrays and isolated clusters of clumps or gaps, an intermediate labyrinthine state, and homogeneous distributions of low to high density may be identified in this parameter space. Then those Turing diffusive instability predictions are compared with both relevant field and laboratory experimental evidence and existing numerical simulations involving differential flow migrating band instabilities for the associated interaction-dispersion-advection mussel-algae model system as well as placed in the context of the results from some recent nonlinear pattern formation studies.
Mean follow-up SB202190 order time of all seven patients was 19.5 (range, 2-60) months. No patient developed recurrence of exposure during follow-up. All patients were fitted with an acceptable prosthesis and had satisfactory cosmetic and functional results.\n\nConclusions: The most common complication of orbital implant is exposure, caused by breakdown of the covering layers, leading to extrusion. Several methods were reported to manage the exposed implants. We report our experience of treating implant exposure with extraocular muscle flaps to establish a well-vascularized environment that supplies both the wrapping material and the overlying
ocular surface tissue. We believe it can work as a good strategy to manage or to prevent orbital implant exposure.”
“While the ecological impacts of invasive species have ZD1839 Protein Tyrosine Kinase inhibitor been demonstrated for many taxonomic groups, the potential effects of behavioural variation among non-native individuals (i.e. personality) on these impacts have been largely overlooked. This is
despite the fact that recent studies have demonstrated that, by nature, the three first stages of biological invasions (i.e. transport, establishment and spread) can lead to personality-biased populations. Freshwater ecosystems provide a unique opportunity to investigate this issue, notably because the ecological impacts of non-native species have been extensively documented and because animal personality has been widely studied using freshwater model species. Here, we aim at developing some perspectives on the potential effects of animal personality CBL0137 purchase on the ecological impacts of freshwater non-native species across levels of biological organizations. At the individual level, personality types have been demonstrated to affect the physiology, metabolism, life history traits and fitness of individuals. We used these effects to discuss how they could subsequently impact invaded populations and, in turn, recipient
communities. We also discussed how these might translate into changes in the structure of food webs and the functioning of invaded ecosystems. Finally we discussed how these perspectives could interact with the management of invasive species.”
“Inactivation of the retinoblastoma (Rb) tumor suppressor protein is widespread in human cancers. Inactivation of Rb is thought to be initiated by association with Raf-1 (C-Raf) kinase, and here we determined how RRD-251, a disruptor of the Rb-Raf-1 interaction, affects pancreatic tumor progression. Assessment of phospho-Rb levels in resected human pancreatic tumor specimens by immunohistochemistry (n – 95) showed that increased Rb phosphorylation correlated with increasing grade of resected human pancreatic adenocarcinomas (P = 0.0272), which correlated with reduced overall patient survival (P = 0.0186).