(C) 2009 Society of Chemical Industry”
“Oxygen has been widely used in neonatal resuscitation for about 300 years. In October 2010, the International Liaison Committee on Neonatal Resuscitation released new guidelines. Based on experimental studies and randomized

clinical trials, the recommendations on evaluation and monitoring of oxygenation status and oxygen supplementation in the delivery room were revised in detail. They include: inaccuracy of oxygenation clinical assessment (colour), mandatory use of pulse oximeter, specific saturation targets and oxygen concentrations during positive pressure ventilation in preterm and term infants. In this review, we describe oxygen management www.selleckchem.com/products/BKM-120.html in the delivery room in terms of clinical assessment, monitoring, treatment and the gap of knowledge.”
“BACKGROUND: This paper

HM781-36B chemical structure reports on the use of a liquid emulsion membrane involving paraffin light oil as membrane phase and lecithin as surfactant for the extraction of alcohol from anthocyanin extract and simulated pineapple wine.

RESULTS: The extraction of alcohol was found to depend on the many factors such as surfactant concentration, contact time, stirring speed, stirring time, and ratio of membrane emulsion to feed volume. Results showed that optimum conditions for maximum alcohol extraction (25%) were lecithin concentration 3%, contact time 20 min, stirring speed 250 rpm and ratio of membrane emulsion to feed volume 1 :2. Multistage extraction using this liquid emulsion

membrane was found to completely remove alcohol from anthocyanin extract and from simulated pineapple wine in seven stages and five stages, respectively.

CONCLUSION: This liquid emulsion membrane was found to be a useful method for the extraction of alcohol from aqueous feed. (C) 2009 Society NU7441 ic50 of Chemical Industry”
“Objective: To discuss the duration and types of breastfeeding and to identify the factors associated with the early introduction of formula milk. Materials and methods: This longitudinal study was conducted in the largest birthing centre of Turin. 562 mother-infant pairs were selected randomly and enrolled from among all the births that occurred in our Hospital from January to December 2009. Data was collected by means of a questionnaire filled out by the researcher during a face-to-face interview at mother’s bed side during her hospital stay. This questionnaire included data regarding maternal socio-demographic, biomedical and hospital-related characteristics and some questions regarding family support, maternal attitude and current knowledge on breastfeeding. Mothers were interviewed by telephone at 1, 3, 6 and 12 months postpartum using the 24-h recall technique and definitions recommended by the WHO to investigate the type of breastfeeding adopted.

“
“Purpose: The aim of this study was to assess the levels and sources of distress in patients with lymphoma. This study Proteases inhibitor also focused on the influence of factors of the level of distress and the cutoff score using the Distress Thermometer (DT) relative

to the Hospital Anxiety and Depression Scale (HADS).

Method: DT and HADS were used to estimate the psychological status of 323 eligible lymphoma patients. The DT was evaluated against the HADS for its sensitivity and specificity.

Results: One hundred and ninety-three (59.7%) lymphoma patients experienced overall distress on the HADS, with 137 (42.4%) experiencing anxiety and 114 (35.3%) suffering from depression. There were 199 (61.6%) and 163 (50.5%) patients with distress score 4 and 5, respectively. DT was significantly correlated with the HADS-total (T) (r=0.820, p<0.001), HADS-depression (D) (r=0.763, p<0.001), and HADS-anxiety (A) (r=0.738, p<0.001). The consistency of the DT and HADS was favorable (coherence index=0.6030, p<0.01) when the cutoff score was 5 for the DT. Referring to the

cutoff of 15 on HADS, 5 on DT yielded optimal specificity (0.869, p<0.001) and sensitivity (0.756, p<0.001). In multiple logistic regression analysis, patients with B symptoms’ were more likely to have a distress score 5 [OR=4.512, ON-01910 manufacturer p<0.05, 95% CI 1.953-10.467].

Conclusion: DT is efficacious for screening for anxiety and depression in lymphoma patients. Copyright (c) 2012 John Wiley & Sons, Ltd.”
“Pharmaceutical aerosols have been targeted to the lungs for the treatment of asthma and pulmonary infectious diseases successfully. Micafungin (Astellas Pharma US, Deerfield,

IL, USA) has been shown to be an effective antifungal agent when administrated intravenously. Pulmonary delivery of micafungin has not previously been reported. In the present pilot study, we characterize the performance of two nebulizers and their potential for delivering micafungin to the lungs as well as the use of multivariate data analysis for mass distribution profile comparison. The concentration of micafungin sodium increased by 21% when delivered by the Acorn II nebulizer and by 20% when delivered by the LC Plus nebulizer, respectively, from the first to the second sampling period. The Ilomastat inhibitor Acorn II nebulizer delivered a fine particle fraction FPF(5.8) (%<5.8 mu m) of 92.5 +/- 0.8 and FPF(3.3) (%<3.3 mu m) of 82.3 +/- 2.1 during the first sampling period. For the LC Plus nebulizer, FPF(5.8) was 92.3 +/- 0.1 and FPF(3.3) was 67.0 +/- 0.7 during the first sampling period. The mass median aerodynamic diameter (MMAD) increased from 1.67 +/- 0.05 to 1.77 +/- 0.04 mu m (Acorn II nebulizer) and from 2.09 +/- 0.01 to 2.20 +/- 0.01 mu m (Pari LC Plus nebulizer) from the first to the second sampling periods. These changes in MMAD were statistically significant by paired t test.

The present study explores the hypothesis that polyethylene components sterilized in a low-oxygen environment undergo similar in SIS3 ic50 vivo oxidative mechanisms as inserts sterilized in air. In addition, the potential influence of the different sterilization processes on the wear performance of the polyethylene components was examined.

Methods: An analysis of oxidation, wear, and surface damage was performed for forty-eight acetabular liners and 123 tibial inserts. The mean implantation time was 12.3 +/- 3.7 years for

thirty-one acetabular liners that had been gamma sterilized in air and 4.0 +/- 2.5 years for the seventeen acetabular liners that had been gamma sterilized in inert gas. The mean implantation time was 11.0 +/- 3.2 years for the twenty-six tibial inserts that had been sterilized in air and 2.8 +/- 2.2 years for the ninety-seven tibial inserts that had been gamma sterilized in inert gas. Oxidation and hydroperoxide levels were characterized in loaded and unloaded regions of the inserts.

Results: Measurable oxidation and oxidation potential were observed in all cohorts. The oxidation and hydroperoxide levels were regional. Surfaces with access to body fluids were more heavily oxidized than

protected bearing surfaces were. This variation appeared to be greater in historical (gamma-in-air-sterilized) components. Regarding wear performance, historical and conventional acetabular liners showed similar wear penetration rates, whereas selleck chemicals a low incidence of delamination was confirmed for the conventional tibial inserts in the first decade of implantation.

Conclusions: The present study explores the impact of industry-wide changes in sterilization practices BV-6 for polyethylene. We found lower oxidation and oxidation potential in the conventional acetabular liners and tibial inserts that had been gamma sterilized in inert gas as compared with the historical

components that had been gamma sterilized in air. However, we also found strong evidence that conventional components undergo mechanisms of in vivo oxidation similar to those observed following gamma irradiation in air. In addition, gamma sterilization in inert gas did not provide polyethylene with a significant improvement in terms of wear resistance as compared with gamma sterilization in air, except for a lower incidence of delamination in the first decade of implantation for tibial inserts.”
“Objective: To determine the prevalence and outcome of higher order multiple (HOM) pregnancies in Lagos, Nigeria.

Methods: The mode of delivery, gestational age, pregnancy and neonatal outcome of babies delivered from HOM pregnancies were reviewed retrospectively from the labor ward and theater registers, neonatal unit admission records and medical notes in a tertiary referral centre from April 2009 to March 2012.

The urgent development of audiological services in other school health centers in the country, particularly those with good referral systems to Ministry of Health hospitals, is needed. Evidence-based

guidelines to identify, monitor, and manage otitis media with effusion (OME) in children in the primary healthcare setting and a strategy to prevent hearing loss are recommended. (C) find more 2012 Elsevier Ireland Ltd. All rights reserved.”
“Objectives: To determine the economic impact of cost-saving alternatives on prescription drug costs for the North Carolina Medicaid medication therapy management (MTM) program and to assess the acceptance of recommendations made by pharmacists to prescribers and the implementation of accepted recommendations.

Design: Retrospective analysis.

Setting: 92 Kerr Drug pharmacies in North Carolina from August 1, 2006, BMS-777607 nmr to July 31, 2007.

Participants: 88 North Carolina Medicaid beneficiaries who received at least 12 prescriptions each month and who completed four quarterly medication reviews by a Kerr Drug pharmacist.

Intervention: Assessed recommendations made by Kerr Drug pharmacists.

Main

outcome measures: Rate of acceptance of pharmacist recommendations and overall economic impact of changing from brand-name medications to cost-saving alternatives.

Results: Acceptance rate of pharmacist recommendations ranged from 42% to 60%. The rate at which the pharmacists’ accepted recommendations were implemented at Kerr Drug pharmacy ranged from 62% to 86% across the four quarterly reviews. Overall economic impact resulted in an average cost savings of $107 per beneficiary to North Carolina Medicaid per year. Quarterly economic impact results revealed that the highest impact occurred during the first quarterly review at $63 per beneficiary.

Conclusion: Prescriber acceptance and pharmacy implementation of cost-savings alternatives provided an annual average cost savings of $9,444 to North Carolina Medicaid. After

pharmacist reimbursement, this savings totaled $2,724.”
“Objective: The aim of this study was to elucidate the involvement of mutations in three relatively common deafness genes A-1210477 in Mexican individuals with non-syndromic hearing loss.

Methods: We sequenced GJB2 for mutations, screened for two deletions involving GJB6, del(GJB6-D1351830) and del(GJB6-D1351854), and for the m.1555A>G mutation in the MTRNR1 gene in 76 (71 simplex and 5 multiplex) unrelated Mexican probands with prelingual non-syndromic hearing loss. Samples were obtained from the Department of Genetics at Instituto Nacional de Rehabilitacion in Mexico City.

Results: Eight previously reported pathogenic variants and two polymorphic variants in GJB2 were identified. The two screened GJB6 deletions and the m.1555A>G mutation were not detected. Eight cases (10.6%) were found to have bi-allelic mutations in GJB2 and six (7.9%) were found to have a monoallelic GJB2 mutation. Of the six monoallelic mutations, one (p.

Hemoglobin and hematocrit levels were targeted at 10.0 g/dL and 30.0% respectively with recombinant human erythropoietin treatment. A diuretic was added or patients decreased their water intake if ANP was more than 43.0 pg/mL or LA diameter (LAD) more than 39 mm, and for other basic markers of volume status. Cardiac function was measured before and after drainage of PD fluid to evaluate the influence of cardiac function.

Results: LAD at start of dialysis (36 +/- 4.6 mm) decreased significantly to 33 +/- 3.3 mm (p < 0.05), 33 +/- 3.2 mm (p < 0.05), and 33 +/- 3.6 mm (p < 0.05) after 6, 12, and 24 months, Selleck AZD9291 respectively. Ejection fraction after

6 months was significantly increased compared with that at start of dialysis (p < 0.05). Left ventricular mass index (LVMI) after 6, 12, and 24 months was significantly decreased compared with that at start of dialysis (p < 0.05). ANP was 56 +/- 39 pg/mL at start of dialysis and decreased significantly to 33 +/- 19 pg/mL after 24 months (p < 0.05). ANP was significantly correlated with LAD (r = 0.412, p < 0.01), transmitral A wave flow velocity (r = 0.429, p < 0.01), and LVMI (r = 0.426, p < 0.01). Instillation of the dialysis fluid did not affect any parameters except inferior vena cava dimension.

Conclusion: This study demonstrates a reduction in LA size and LVMI in PD patients followed over 24

months. Left ventricular structure, contraction, and compliance were well preserved in PD patients undergoing aggressive GNS-1480 in vitro treatment based on measurements of plasma ANP and LAD.”
“Objectives: There is a need for standardization in systemic sclerosis (SSc) management.

Methods: SSc experts (n = 117) were sent JAK inhibitor 3 surveys to gain

consensus for SSc management.

Results: First-line therapy for scleroderma renal crisis (SRC) was an angiotensin-converting enzyme inhibitor (ACEi). For SRC there were not many differences between treating mild or severe SRC. In general, Second-line was to add either a calcium channel blocker (CCB) or angiotensin receptor blocker (ARB) and then an alpha-blocker (66% agreed). Endothelin receptor agonists (ERAs) were the first treatment in mild pulmonary arterial hypertension (PAH) (72%), followed by adding a phosphodiesterase-5 inhibitor (PDE5i) (77%) and then a prostanoid (73%). For severe PAH, initial treatment was 1 of the following: a prostanoid (49%), combination of a ERA and a PDE5i (18%), or combination of a ERA and a prostanoid (16%) (71% agreed). For mild Raynaud’s phenomenon (RF), after a CCB and adding a PDE5i (35%), trying an ARB (32%) and finally a prostanoid (23%) was suggested. For more severe RF, 54% agreed on adding a PDE5i (45%) or prostanoid (32%) to a CCB. In the prevention of digital ulcers (DU), initial treatment was a CCB (73%), then adding a PDE5i, then use of a ERA, and then a prostanoid (44% agreed).

Also this microemulsion

showed the best performance in the antifungal activity test compared with the one containing propylene glycol. These results are according to previous reports of the advantages of microemulsions BIX 01294 in vitro for topical administration and they are very promising for further clinical evaluation.”
“Strategies to decrease intracellular polyamine levels have been studied for their efficacy in reducing colorectal cancer (CRC) risk. A successful strategy combined agents that decreased polyamine synthesis by inhibiting ornithine decarboxylase with difluoromethylornithine (DFMO), and increased cellular export of polyamines by activating the spermidine/spermine acetyl transferase with non-steroidal anti-inflammatory drugs (NSAIDs). A Phase III trial treating resected adenoma patients with DFMO plus sulindac demonstrated marked reduction of metachronous adenomas, advanced adenomas and multiple adenomas compared to placebo. This 4EGI-1 combination regimen was well-tolerated, however there was a non-significant excess of cardiovascular events in the treatment arm compared to placebo as well as modest ototoxicity. Targeting this therapy to people at elevated risk of CRC, and employing clinical and genetic predictors, should improve patient

benefit and reduce the risk of side effects to improve the acceptability of this strategy. (C) 2011 Elsevier Ltd. All rights reserved.”
“This paper presents a theoretical study of the effect of transverse electric potentials on the transport properties of armchair graphene nanoribbons (AGNRs), 5-Fluoracil formed by pairs of asymmetric gates placed along the side of

the ribbon. Single-pair and dual-pair configurations are considered. The effect of hollows (spatial regions void of carbon atoms) in the AGNR channels is also examined. The use of hollowed AGNRs in the dual-pair configuration allows for significant modulation of the transport gap when the two pairs have opposite gate bias polarity. Furthermore, for the dual-gate system, hollowed AGNR channels exhibit the optimal ratio of on-state to off-state conductance, due to the smaller off-state conductance compared with spatially homogenous AGNR channels. Our results indicate that transverse gate technology coupled with careful engineering of hollow geometry may lead to possible applications in graphene-based electronic devices. (C) 2011 American Institute of Physics. [doi:10.1063/1.3562155]“
“The water-insoluble procedures in US Pharmacopeia (USP) General Chapter Residual Solvents < 467 >, which are based on European Pharmacopoeia procedures, were optimized and modified before their inclusion in the chapter to improve their scope, performance, and ruggedness. The optimized procedures use a static headspace introduction system with a gas chromatograph equipped with a flame ionization detector.

Their high level of expression at the blood-brain, maternal-fetal, and

blood-testis barriers as well as their purported roles in oral absorption suggests that ABC transporters play important pharmacologic roles. Methods: We have developed a method to characterize the function and inhibition of ABC transporters using an automated cell counter with fluorescence detection capability. The assay was performed using stably-transfected HEK293 cells expressing P-gp, MRP1, or ABCG2 and examining transport of fluorescent substrates in the presence or absence of known inhibitors and compared to results obtained PHA-848125 with a flow cytometer. Fold increase in intracellular fluorescence was then calculated for cells incubated with fluorescent substrate in the absence of inhibitor versus in the presence of inhibitor. Results: Fold increase values obtained either with the cell counter or flow cytometer were comparable for cells expressing either MRP1 or ABCG2; slightly higher fold increase values were observed when cells expressing P-gp were read on a flow cytometer compared to the cell counter.

Discussion: The assay described provides an inexpensive detection method to aid in the development of Mocetinostat inhibitor novel ABC transporter inhibitors or to characterize potential drug-drug interactions. Published by Elsevier Inc.”
“The first aim of this study was to translate the Neck Pain and Disability Scale (NPAD) from English into Dutch producing the NPAD-Dutch Language ACY-738 cell line Version (DLV). The second aim was to analyze test-retest reliability and agreement of the NPAD-DLV and the Neck Disability Index (NDI)-DLV. The NPAD was translated according to established guidelines. Thirty-four patients (mean age 37.5 years, 68% female) with chronic neck pain (CNP), within an outpatient rehabilitation

setting, participated in this study. The NPAD-DLV and the NDI-DLV were filled out twice with a mean test-retest interval of 18 days. The intraclass correlation coefficient of the NPAD-DLV was 0.76 (95% confidence interval (CI) 0.57-0.87) and of the NDI-DLV 0.84 (95% CI 0.69-0.92). The limits of agreement of the NPAD-DLV and the NDI-DLV were, respectively, +/- 20.9 (scale 0-100) and +/- 6.5 (scale 0-50). The reliability of the NPAD-DLV and the NDI-DLV was acceptable for patients with CNP. The variation (‘instability’) in the NPAD-DLV total scores was relatively large and larger than the variation of the NDI-DLV.”
“Background: The impact of the Papanicolaou (Pap) smear on the prevention of cervical cancer is one of the greatest public health success stories. However, it is not clear if women understand the purpose of the Pap smear despite recent advancements and national attention over cervical cancer prevention.

05). Conversely, MPH P5091 and DMA at very low concentrations (<= 0.25% v/v) induced cell toxicity. However, up to 2.0% v/v MPH and (DMA) had no effect on TEER and SF permeation. No obvious change in actin staining was observed for DMSO (15%), Cremophor (R) EL (15%), and MPA (1%). However, the actin architecture for cells treated with DMA (1%) and PEG 400 (15%) appeared significantly different from control. Based on this study Cremophor (<= 10%), PEG 400 (<= 5%), and DMSO (<= 5%), and low concentrations of DMA and MPA (<= 0.25%) were suitable for

in vitro studies with Calu-3 cells.”
“For decades the vitamin D biological system has been considered almost exclusively as the master integrator of calcium-phosphate homeostasis and bone metabolism. More recently, the discovery that many human tissues and cells, which do not directly participate in mineral ion homeostasis, express the vitamin D receptor (VDR) and are able to convert the circulating

pro-hormone 25-hydroxyvitamin D in its active form, 1,25-dihydroxyvitamin D, has provided new insights into the biological function of this peculiar endocrine system. Several reports have highlighted a variety of human diseases possibly related to vitamin D insufficiency or deficiency (respectively Metabolism inhibitor defined as 25-hydroxyvitamin D serum levels lower than 30 or lower than 20 ng/ml). In particular, experimental and observational studies, including those published in this journal issue, support the concept that vitamin D deficiency is involved in the pathogenesis of congestive heart failure, a disabling condition affecting over 15 million of patients worldwide. Considering that circulating levels of 25-hydroxyvitamin D represent the accepted clinical indicator of individual vitamin D status, the measurement of this pro-hormone can be regarded WZB117 ic50 as an appropriate and cost-effective screening tool in patients with chronic heart failure. (C) 2010 Published by Elsevier B.V.”
“Topical

application of the drugs at the pathological sites offers potential advantages of delivering the drug directly to the site of action. The main aim of this work was to formulate and evaluate Miconazole nitrate (MN) loaded solid lipid nanoparticles (SLN) for topical application. MN-loaded SLN were prepared by modified solvent injection method and characterized for shape, surface morphology, particle size, and drug entrapment. These solid lipid nanoparticles were spherical in shape with smooth surface and possessed mean average size of 206.39 +/- 9.37 nm. In vitro drug release of MN-loaded SLN-bearing hydrogel was compared with MN suspension and MN hydrogel; MN-loaded SLN-bearing hydrogel depicted a sustained drug release over a 24-h period. Tape stripping experiments demonstrated 10-fold greater retention with MN-loaded SLN-bearing hydrogel as compared to MN suspension and MN hydrogel. The in vivo studies were performed by infecting the rats with candida species.

This disease primarily affects children and is characterized by hepatic and pulmonary dysfunction, neurodegeneration and death at an early age. Currently, there is no effective treatment for NPC disease. It was recently discovered that 2-hydroxypropyl-beta-cyclodextrin (2HPBCD), when administered systemically to a murine model of either NPC1 or NPC2 disease, significantly reduced lysosomal cholesterol accumulation in almost every organ, delayed the progression of neurodegeneration and significantly prolonged lifespan by allowing trapped

cholesterol within the late endosome/lysosome to be released. When 2HPBCD was administered directly into the CNS of Npc1(-/-) mice, neurodegeneration was completely prevented. This review will Selleckchem HDAC inhibitor explore the pathophysiology of NPC disease and the use of CX-6258 order 2HPBCD as a possible therapeutic modality.”
“Study Design. Analysis of Roland Morris Disability Questionnaire (RMDQ) and Oswestry Disability Index (Oswestry) responses.

Objective. To determine the prevalence of unanswered questions on the RMDQ23 (23-item RMDQ version) and Oswestry questionnaires. To determine whether managing RMDQ23 missing data using proportional

recalculation is more accurate than simply ignoring missing data.

Summary of Background Data. It is likely that the most common method for calculating an RMDQ sum score is to simply ignore any unanswered questions. In contrast, the raw sum score on the Oswestry is converted to a 0 to 100 scale, with the advantage of allowing missing data to be accommodated by proportional recalculation.

Methods. The prevalence of unanswered RMDQ23 questions was measured in a research project and a routine care setting. The accuracy of the RMDQ23 proportional recalculation method was measured using 311 fully completed RMDQ23 and matching Oswestry questionnaire sets. Raw sum scores were calculated, and questions systematically dropped. At each stage, sum scores were converted to a score on a 0 to 100 scale and the error calculated. Wilcoxon Tests were used to compare the magnitude of the error scores.

Results. MLN8237 Cell Cycle inhibitor The prevalence of people who did not answer one

or more questions was 29.5% (RMDQ23) in routine care, and 13.9% (Oswestry) and 20.3% (RMDQ23) in a research project. Proportional recalculation was a more accurate method to calculate RMDQ sum scores than simply ignoring missing data, when two or more questions were unanswered.

Conclusion. Because of less error when missing data are present, the most accurate method for expressing RMDQ sum scores This conversion method is (a) if all questions are answered or only one question is unanswered, multiply the raw sum score by 100 divided by the total number of questions, and (b) if two or more questions are unanswered, multiply the raw sum score by 100 divided by the number of answered questions.”
“T lymphocytes recognize foreign antigens presented by donor or recipient cells through the direct and indirect pathways respectively.

After evaluation of myocardial contraction, hearts were excised at 2, 10, 40, and 60 days for investigation of vasculopathy, gene expression, enzymatic activities, and mitochondrial respiration. Gene expression studies

identified a gene cluster coding for subunits of the mitochondrial electron transport chain regulated in response to CI and CR. Myocardial performance, SB525334 mitochondrial function, and mitochondrial marker enzyme activities declined in all allografts with time after transplantation. These declines were more rapid and severe in CI allografts (CR-CI) and correlated well with progression of vasculopathy and fibrosis. Mitochondria related gene expression and mitochondrial function are substantially compromised with the progression of CR and show that CI impacts on progression, gene profile, and mitochondrial function of CR. Monitoring mitochondrial function and enzyme activity

might allow for earlier detection of CR and cardiac allograft dysfunction.”
“CLAVATA1 (CLV1), CLV2, CLV3, CORYNE (CRN), BAM1 and BAM2 are key regulators that function at the shoot apical meristem (SAM) of plants to promote differentiation by limiting the size of the organizing center that maintains stem cell identity in neighboring cells. Previous results have indicated that the extracellular domain of the receptor kinase CLV1 binds to the CLV3-derived CLE ligand. The biochemical role of the receptor-like protein CLV2 has remained largely unknown. Although genetic analysis suggested that CLV2, together with the membrane kinase CRN, acts in

parallel with CLV1, recent studies using transient expression indicated Compound C research buy JQ-EZ-05 cell line that CLV2 and CRN from a complex with CLV1. Here, we report detection of distinct CLV2-CRN heteromultimeric and CLV1-BAM multimeric complexes in transient expression in tobacco and in Arabidopsis meristems. Weaker interactions between the two complexes were detectable in transient expression. We also find that CLV2 alone generates a membrane-localized CLE binding activity independent of CLV1. CLV2, CLV1 and the CLV1 homologs BAM1 and BAM2 all bind to the CLV3-derived CLE peptide with similar kinetics, but BAM receptors show a broader range of interactions with different CLE peptides. Finally, we show that BAM and CLV1 overexpression can compensate for the loss of CLV2 function in vivo. These results suggest two parallel ligand-binding receptor complexes controlling stem cell specification in Arabidopsis.”
“Chrysophyllum cainito is a plant recognized by the traditional healers of Aboude-Mandeke, a village in the Department of Agboville (Cote-d’Ivoire), as having antidiabetic properties. The aim of this study is to evaluate, experimentally, the effect of an aqueous decoction of the plant’s leaves that we called C. cainito, on rabbits induced with alloxane, a diabetogenic product. Different graded doses of this herbal medicine were applied on postprandial blood sugar levels of diabetic rabbits.